P2ry1 - purinergic receptor P2Y1 (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-18
Description
Enables several functions, including A1 adenosine receptor binding activity; G protein-coupled purinergic nucleotide receptor activity; and adenyl ribonucleotide binding activity. Involved in several processes, including positive regulation of phosphate metabolic process; purinergic nucleotide receptor signaling pathway; and regulation of secretion by cell. Located in several cellular components, including basolateral plasma membrane; postsynaptic density; and postsynaptic membrane. Is active in glutamatergic synapse and presynaptic active zone membrane. Used to study impotence. Orthologous to human P2RY1 (purinergic receptor P2Y1).
- P2y
- P2y1
- P2Y purinoceptor 1
- ATP receptor
- P2 purinoreceptor subclass 2Y
- P2Y ATP receptor 1
- purinergic receptor P2Y, G-protein coupled, 1
- P2Y1 Receptor
- P2Y1 Purinoceptor
- P2Y1 Purinoceptors
- P2Y1 Receptors
- Purinoceptor P2Y1
- Purinergic Receptor P2Y, G-Protein Coupled, 1
Receptor for extracellular adenine nucleotides such as ADP (PMID: 7779087). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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