Psmb8 - proteasome 20S subunit beta 8 (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-17
Description
Predicted to enable endopeptidase activity. Predicted to be involved in fat cell differentiation; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of endopeptidase activity. Predicted to act upstream of or within antigen processing and presentation. Predicted to be located in cytoplasm. Predicted to be part of proteasome core complex, beta-subunit complex and spermatoproteasome complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in proteasome-associated autoinflammatory syndrome 1. Orthologous to human PSMB8 (proteasome 20S subunit beta 8).
- Lmp7
- Ring10
- proteasome subunit beta type-8
- large multifunctional protease 7
- low molecular mass polypeptide 7
- macropain subunit C13
- multicatalytic endopeptidase complex subunit C13
- proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
- proteasome (prosome, macropain) subunit, beta type, 8
- proteasome component C13
- proteasome subunit beta 8
- proteasome subunit beta type-8-like
- proteasome subunit beta-5i
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. May participate in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (By similarity). Required for adipocyte differentiation (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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