Tbxas1 - thromboxane A synthase 1 (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-17
Description
Predicted to enable heme binding activity; hydroperoxy icosatetraenoate dehydratase activity; and thromboxane-A synthase activity. Involved in several processes, including intracellular chloride ion homeostasis; positive regulation of vasoconstriction; and response to ethanol. Predicted to be located in cytosol and endoplasmic reticulum membrane. Used to study acute necrotizing pancreatitis; artery disease (multiple); brain infarction; glomerulonephritis (multiple); and thrombosis. Biomarker of hydronephrosis. Human ortholog(s) of this gene implicated in Ghosal hematodiaphyseal syndrome and cerebral infarction. Orthologous to human TBXAS1 (thromboxane A synthase 1).
- thromboxane-A synthase
- TXA synthase
- TXS
- ThromboxA ane synthase 1
- cytochrome P450 5A1
- hydroperoxy icosatetraenoate dehydratase
- thromboxane A synthase 1, platelet
- Thromboxane A Synthase
- Thromboxane A2 Synthetase
- Thromboxane Synthetase
- TBXAS1 (human)
- TBXAS1 (black-footed ferret)
- TBXAS1 (European mink)
- TBXAS1 (Ahaetulla prasina)
- TBXAS1 (red-backed fairy wren)
- TBXAS1 (Oenanthe melanoleuca)
- TBXAS1 (Chinese forest musk deer)
- TBXAS1 (raccoon dog)
- TBXAS1 (Leopard gecko)
- TBXAS1 (Pteronotus mesoamericanus)
- TBXAS1 (black-legged kittiwake)
- TBXAS1 (Aeolian wall lizard)
- TBXAS1 (graceful crag lizard)
- TBXAS1 (lesser prairie-chicken)
- TBXAS1 (takin)
- TBXAS1 (yellow-footed antechinus)
- TBXAS1 (California condor)
- TBXAS1 (Macaca thibetana thibetana)
- TBXAS1 (Northern goshawk)
- TBXAS1 (snow leopard)
- TBXAS1 (rock ptarmigan)
- TBXAS1 (Loggerhead turtle)
- TBXAS1 (Sphaerodactylus townsendi)
- TBXAS1 (Eurasian river otter)
- TBXAS1 (bobcat)
- TBXAS1 (greater spear-nosed bat)
- TBXAS1 (American black bear)
- TBXAS1 (Ring-tailed lemur)
- TBXAS1 (Agile Gracile Mouse Opossum)
- TBXAS1 (Komodo dragon)
- TBXAS1 (Asiatic toad)
- TBXAS1 (American mink)
- TBXAS1 (leopard cat)
- TBXAS1 (wapiti)
- TBXAS1 (Arctic fox)
- TBXAS1 (rufous-necked snowfinch)
- TBXAS1 (white-rumped snowfinch)
- TBXAS1 (jaguarundi)
- TBXAS1 (common toad)
- TBXAS1 (common frog)
- TBXAS1 (scimitar-horned oryx)
- TBXAS1 (Barn swallow)
- TBXAS1 (large flying fox)
- TBXAS1 (Eurasian tree sparrow)
- TBXAS1 (Reeves's turtle)
- TBXAS1 (Tiger rattlesnake)
- TBXAS1 (striped hyena)
- TBXAS1 (leatherback sea turtle)
- TBXAS1 (Iberian mole)
- TBXAS1 (Jamaican fruit-eating bat)
- TBXAS1 (Sturnira hondurensis)
- TBXAS1 (Kuhl's pipistrelle)
- TBXAS1 (Myotis myotis)
- TBXAS1 (Pallas's mastiff bat)
- TBXAS1 (black swan)
- TBXAS1 (common lizard)
- TBXAS1 (Southern elephant seal)
- TBXAS1 (Trachemys scripta elegans)
- TBXAS1 (Pantherophis guttatus)
- TBXAS1 (Gaboon caecilian)
- TBXAS1 (Francois's langur)
- TBXAS1 (greater horseshoe bat)
- TBXAS1 (Abingdon island giant tortoise)
- TBXAS1 (silvery gibbon)
- TBXAS1 (vaquita)
- TBXAS1 (tufted duck)
- TBXAS1 (ring-necked pheasant)
- TBXAS1 (Kakapo)
- TBXAS1 (Microcaecilia unicolor)
- TBXAS1 (Aquila chrysaetos chrysaetos)
- TBXAS1 (Common wall lizard)
- TBXAS1 (pale spear-nosed bat)
- TBXAS1 (Steller sea lion)
- TBXAS1 (willow flycatcher)
- TBXAS1 (California sea lion)
- TBXAS1 (burrowing owl)
- TBXAS1 (eastern brown snake)
- TBXAS1 (mainland tiger snake)
- TBXAS1 (brown bear)
- TBXAS1 (emu)
- TBXAS1 (Okarito brown kiwi)
- TBXAS1 (Nothoprocta perdicaria)
- TBXAS1 (red fox)
- TBXAS1 (puma)
- TBXAS1 (dingo)
- TBXAS1 (gelada)
- TBXAS1 (Yangtze finless porpoise)
- TBXAS1 (common vampire bat)
- TBXAS1 (blue tit)
- TBXAS1 (Ugandan red Colobus)
- TBXAS1 (beluga whale)
- TBXAS1 (Hawaiian monk seal)
- TBXAS1 (white-rumped munia)
- TBXAS1 (helmeted guineafowl)
- TBXAS1 (koala)
- TBXAS1 (central bearded dragon)
- TBXAS1 (zebu cattle)
- TBXAS1 (great roundleaf bat)
- TBXAS1 (Australian saltwater crocodile)
- TBXAS1 (Gharial)
- TBXAS1 (leopard)
- TBXAS1 (Nanorana parkeri)
- TBXAS1 (black snub-nosed monkey)
- TBXAS1 (Malayan pangolin)
- TBXAS1 (Panamanian white-faced capuchin)
- TBXAS1 (Miniopterus natalensis)
- TBXAS1 (Egyptian rousette)
- TBXAS1 (Japanese quail)
- TBXAS1 (Taiwan habu)
- TBXAS1 (Great Tit)
- TBXAS1 (cheetah)
- TBXAS1 (Common starling)
- TBXAS1 (ass)
- TBXAS1 (Thamnophis sirtalis)
- TBXAS1 (North Island brown kiwi)
- TBXAS1 (Swan goose)
- TBXAS1 (gray mouse lemur)
- TBXAS1 (Coquerel's sifaka)
- TBXAS1 (sooty mangabey)
- TBXAS1 (drill)
- TBXAS1 (Colobus angolensis palliatus)
- TBXAS1 (pig-tailed macaque)
- TBXAS1 (large flying fox)
- TBXAS1 (Arabian camel)
- TBXAS1 (Bactrian camel)
- TBXAS1 (Bison bison bison)
- TBXAS1 (bald eagle)
- TBXAS1 (Corvus cornix cornix)
- TBXAS1 (golden snub-nosed monkey)
- TBXAS1 (East African grey crowned-crane)
- TBXAS1 (White-tailed tropicbird)
- TBXAS1 (speckled mousebird)
- TBXAS1 (brown roatelo)
- TBXAS1 (chuck-will's-widow)
- TBXAS1 (sunbittern)
- TBXAS1 (Buceros rhinoceros silvestris)
- TBXAS1 (Macqueen's bustard)
- TBXAS1 (Kea)
- TBXAS1 (chimney swift)
- TBXAS1 (red-crested turaco)
- TBXAS1 (common barn owl)
- TBXAS1 (cuckoo roller)
- TBXAS1 (hoatzin)
- TBXAS1 (white-tailed eagle)
- TBXAS1 (Downy woodpecker)
- TBXAS1 (killdeer)
- TBXAS1 (bar-tailed trogon)
- TBXAS1 (red-throated loon)
- TBXAS1 (Red-legged seriema)
- TBXAS1 (African ostrich)
- TBXAS1 (little egret)
- TBXAS1 (Northern fulmar)
- TBXAS1 (common cuckoo)
- TBXAS1 (great cormorant)
- TBXAS1 (Dalmatian pelican)
- TBXAS1 (crested ibis)
- TBXAS1 (Adelie penguin)
- TBXAS1 (emperor penguin)
- TBXAS1 (Common canary)
- TBXAS1 (rifleman)
- TBXAS1 (carmine bee-eater)
- TBXAS1 (polar bear)
- TBXAS1 (American crow)
- TBXAS1 (Sunda flying lemur)
- TBXAS1 (Przewalski's horse)
- TBXAS1 (big brown bat)
- TBXAS1 (green monkey)
- TBXAS1 (Yangtze River dolphin)
- TBXAS1 (Burmese python)
- TBXAS1 (minke whale)
- TBXAS1 (sperm whale)
- TBXAS1 (tiger)
- TBXAS1 (Green sea turtle)
- TBXAS1 (black flying fox)
- TBXAS1 (Myotis davidii)
- TBXAS1 (American alligator)
- TBXAS1 (alpaca)
- TBXAS1 (Wild Bactrian camel)
- TBXAS1 (Chinese tree shrew)
- TBXAS1 (Chinese soft-shelled turtle)
- TBXAS1 (little brown bat)
- TBXAS1 (water buffalo)
- TBXAS1 (Chinese alligator)
- TBXAS1 (coelacanth)
- TBXAS1 (wild yak)
- TBXAS1 (Brandt's bat)
- TBXAS1 (goat)
- TBXAS1 (crab-eating macaque)
- TBXAS1 (Tibetan ground-tit)
- TBXAS1 (rock pigeon)
- TBXAS1 (white-throated sparrow)
- TBXAS1 (Saker falcon)
- TBXAS1 (medium ground-finch)
- Tbxas1 (long-tailed chinchilla)
- TBXAS1 (western painted turtle)
- TBXAS1 (peregrine falcon)
- TBXAS1 (Collared flycatcher)
- TBXAS1 (mallard)
- TBXAS1 (domestic ferret)
- TBXAS1 (small Madagascar hedgehog)
- TBXAS1 (European shrew)
- TBXAS1 (American pika)
- TBXAS1 (nine-banded armadillo)
- TBXAS1 (Pacific walrus)
- TBXAS1 (killer whale)
- TBXAS1 (western lowland gorilla)
- TBXAS1 (sheep)
- TBXAS1 (domestic cat)
- TBXAS1 (Bolivian squirrel monkey)
- TBXAS1 (olive baboon)
- TBXAS1 (pygmy chimpanzee)
- TBXAS1 (small-eared galago)
- TBXAS1 (Tasmanian devil)
- TBXAS1 (African savanna elephant)
- TBXAS1 (northern white-cheeked gibbon)
- TBXAS1 (giant panda)
- TBXAS1 (white-tufted-ear marmoset)
- TBXAS1 (rabbit)
- tbxas1 (tropical clawed frog)
- TBXAS1 (zebra finch)
- TBXAS1 (Sumatran orangutan)
- TBXAS1 (platypus)
- TBXAS1 (horse)
- TBXAS1 (gray short-tailed opossum)
- tbxas1 (zebrafish)
- TBXAS1 (Rhesus monkey)
- TBXAS1 (domestic cattle)
- TBXAS1 (dog)
- TBXAS1 (chimpanzee)
- TBXAS1 (chicken)
- TBXAS1 (pig)
- Tbxas1 (house mouse)
Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Cleaves also PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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- STRING: functional protein association networks
- Swiss Institute of Bioinformatics Bgee
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