Mbp - myelin basic protein (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-17
Description
The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called "Golli-Mbp") that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the 'shiverer' and 'myelin deficient' phenotypes in mouse. [provided by RefSeq, Jul 2008]
A structural constituent of myelin sheath. Involved in several processes, including negative regulation of axonogenesis; response to progesterone; and response to tumor necrosis factor. Located in cell surface and compact myelin. Used to study demyelinating disease. Biomarker of Huntington's disease; brain disease (multiple); diabetic neuropathy; hypothyroidism; and schizophrenia. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human MBP (myelin basic protein).
- Mbps
- Golli-Mbp
- MBP S
- myelin basic protein Golli-mbp
- myelin basic protein S
- Golli-MBP1 Protein
- Golli-MBP2 Protein
- HOG5 Protein
- HOG7 Protein
- MBP2 Protein
- MBP3 Protein
- MBP1 Protein
- MBP4 Protein
- Myelin Basic Protein, Isoform 1
- Myelin Basic Protein, Isoform 7
- Myelin Basic Protein, 18.5 kDa Isoform
- Myelin Basic Protein, Isoform 4
- Myelin Basic Protein, 21.5 kDa Isoform
- Myelin Basic Protein, Isoform 2
- Myelin Basic Protein, Isoform 5
- Myelin Basic Protein, 17.2 kDa Isoform
- Myelin Basic Protein, 20.2 kDa Isoform
- Myelin Basic Protein, Isoform 3
- Myelin Basic Protein, Isoform 6
Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity).
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
- NCBI GeneLICENSENCBI Website and Data Usage Policies and Disclaimershttps://www.ncbi.nlm.nih.gov/home/about/policies/
- PubChem
- Medical Subject Headings (MeSH)LICENSEWorks produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.https://www.nlm.nih.gov/copyright.htmlMyelin Basic Proteinhttps://meshb.nlm.nih.gov/record/ui?ui=D004676
- Alliance of Genome ResourcesLICENSEAll annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).https://www.alliancegenome.org/privacy-warranty-licensing
- BioGRIDLICENSEThe MIT License (MIT); Copyright Mike Tyers Labhttps://wiki.thebiogrid.org/doku.php/terms_and_conditions
- STRING: functional protein association networks
- NCBI Gene Expression Omnibus (GEO)
- Rat Genome Database (RGD)LICENSECreative Commons Attribution 4.0 International license (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/
- Swiss Institute of Bioinformatics Bgee
- UniProtLICENSEWe have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.https://www.uniprot.org/help/license
- VEuPathDB: The Eukaryotic Pathogen, Vector and Host Informatics ResourceLICENSEAll data on VEuPathDB websites are provided freely for public use.https://veupathdb.org/veupathdb/app/static-content/about.html
- Wikidata
- AlphaFold DBLICENSEAll of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.https://alphafold.ebi.ac.uk/faq
CONTENTS