Junb - JunB proto-oncogene, AP-1 transcription factor subunit (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-17
Description
Enables DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including response to 4-nitroquinoline N-oxide; response to corticosterone; and response to progesterone. Predicted to be located in nucleoplasm. Predicted to be part of transcription factor AP-1 complex. Biomarker of renal carcinoma. Human ortholog(s) of this gene implicated in head and neck squamous cell carcinoma and melanoma. Orthologous to human JUNB (JunB proto-oncogene, AP-1 transcription factor subunit).
- transcription factor JunB
- Jun-B oncogene
- jun B proto-oncogene
- transcription factor AP-1 subunit JunB
- transcription factor jun-B
Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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