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Gusb - glucuronidase, beta (Norway rat)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-17
Description
Enables beta-glucuronidase activity and carbohydrate binding activity. Predicted to be involved in chondroitin sulfate catabolic process; heparan sulfate proteoglycan catabolic process; and hyaluronan catabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in extracellular space and lysosomal lumen. Biomarker of mucopolysaccharidosis and peritonitis. Human ortholog(s) of this gene implicated in Sly syndrome. Orthologous to human GUSB (glucuronidase beta).

1 Names and Identifiers

1.1 Synonyms

  • Ac2-223
  • Gus-s
  • beta-glucuronidase

1.1.1 MeSH Entry Terms

  • Endoglucuronidase
  • Endo-beta-D-Glucuronidase
  • Exo-beta-D-Glucuronidase
  • beta-Glucuronidase

1.2 Other Identifiers

1.2.1 Ensembl ID

1.2.2 Alliance Gene ID

1.2.3 Enzyme Commission (EC) Number

1.2.4 GlyCosmos Gene

1.2.5 RGD ID

1.2.6 Wikidata

3 Proteins

3.1 Protein Function

Plays an important role in the degradation of dermatan and keratan sulfates.

3.2 Protein 3D Structures

3.2.1 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

3.3 Protein Targets

4 Chemicals and Bioactivities

4.1 Tested Compounds

5 BioAssays

5.1 Small-Molecule BioAssays

6 Interactions and Pathways

6.1 Interactions

6.2 Pathways

7 Biochemical Reactions

8 Expression

9 Literature

9.1 Consolidated References

9.2 NLM Curated PubMed Citations

9.3 Gene-Chemical Co-Occurrences in Literature

9.4 Gene-Gene Co-Occurrences in Literature

9.5 Gene-Disease Co-Occurrences in Literature

10 Patents

10.1 Gene-Chemical Co-Occurrences in Patents

10.2 Gene-Gene Co-Occurrences in Patents

10.3 Gene-Disease Co-Occurrences in Patents

11 Classification

11.1 MeSH Tree

11.2 Gene Ontology: Biological Process

11.3 Gene Ontology: Cellular Component

11.4 Gene Ontology: Molecular Function

11.5 ChEMBL Target Tree

11.6 Enzyme Classification

12 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Medical Subject Headings (MeSH)
    LICENSE
    Works produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.
    https://www.nlm.nih.gov/copyright.html
  4. Alliance of Genome Resources
    LICENSE
    All annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
    https://www.alliancegenome.org/privacy-warranty-licensing
  5. GlyCosmos Glycoscience Portal
    LICENSE
    All copyrightable parts of the datasets in GlyCosmos are under the Creative Commons Attribution (CC BY 4.0) License.
    https://glycosmos.org/license
  6. NCBI Gene Expression Omnibus (GEO)
  7. Rat Genome Database (RGD)
    LICENSE
    Creative Commons Attribution 4.0 International license (CC BY 4.0)
    https://creativecommons.org/licenses/by/4.0/
  8. STRING: functional protein association networks
  9. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  10. Wikidata
  11. ChEMBL
    LICENSE
    Access to the web interface of ChEMBL is made under the EBI's Terms of Use (http://www.ebi.ac.uk/Information/termsofuse.html). The ChEMBL data is made available on a Creative Commons Attribution-Share Alike 3.0 Unported License (http://creativecommons.org/licenses/by-sa/3.0/).
    http://www.ebi.ac.uk/Information/termsofuse.html
  12. Swiss Institute of Bioinformatics ENZYME
    LICENSE
    Copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/).
    https://enzyme.expasy.org/enzyme.get
    Enzyme Classification
    https://enzyme.expasy.org/
  13. Gene Ontology (GO)
    LICENSE
    Gene Ontology Consortium data and data products are licensed under the Creative Commons Attribution 4.0 Unported License (https://creativecommons.org/licenses/by/4.0/legalcode)
    http://geneontology.org/docs/go-citation-policy/
  14. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
  15. Rhea - annotated reactions database
    LICENSE
    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
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