Adamts15 - ADAM metallopeptidase with thrombospondin type 1 motif 15 (house mouse)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-02-02
Description
This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active versicanase enzyme. This gene is located adjacent to a related ADAMTS gene (Adamts8) on chromosome 9. [provided by RefSeq, Jul 2016]
Enables endopeptidase activity; extracellular matrix binding activity; and heparin binding activity. Involved in extracellular matrix disassembly and myoblast fusion. Located in cell surface and extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and skin. Human ortholog(s) of this gene implicated in distal arthrogryposis. Orthologous to human ADAMTS15 (ADAM metallopeptidase with thrombospondin type 1 motif 15).
- A disintegrin and metalloproteinase with thrombospondin motifs 15
- a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 15
- a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 15
Metalloprotease which has proteolytic activity against the proteoglycan VCAN, cleaving it at the 'Glu-1401-
-1402-Ala' site (PMID: 24220035). Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration (PMID: 23233679).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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