Zp2 - zona pellucida glycoprotein 2 (house mouse)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-18
Description
This gene encodes a member of the zona pellucida family of glycoproteins that play an important role in the survival of growing oocytes, successful fertilization and the passage of early embryos through the oviduct. The encoded preproprotein undergoes proteolytic processing to generate the mature polypeptide that is incorporated into the extracellular matrix surrounding mouse oocytes. Mice lacking the encoded protein develop defective zonae pellucidae that disrupt folliculogenesis, fertility and development. [provided by RefSeq, Sep 2016]
Predicted to enable acrosin binding activity and identical protein binding activity. Predicted to be a structural constituent of egg coat. Involved in binding activity of sperm to zona pellucida and prevention of polyspermy. Located in several cellular components, including collagen-containing extracellular matrix; endoplasmic reticulum; and multivesicular body. Is expressed in germ cell of ovary; oocyte; ovary; secondary oocyte; and testis. Orthologous to human ZP2 (zona pellucida glycoprotein 2).
- Zp-2
- zona pellucida sperm-binding protein 2
- zona pellucida glycoprotein ZP2
- zona pellucida protein A
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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