Uck1 - uridine-cytidine kinase 1 (house mouse)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-02-01
Description
Enables uridine kinase activity. Involved in UMP salvage. Predicted to be active in cytoplasm. Is expressed in nervous system; respiratory system; and urinary system. Orthologous to human UCK1 (uridine-cytidine kinase 1).
- URK1
- Umpk
- cytidine monophosphokinase 1
- uridine monophosphate kinase
- uridine monophosphokinase 1
Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate (PMID: 8951040). Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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