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Stx3 - syntaxin 3 (house mouse)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-29
Description
Predicted to enable SNAP receptor activity; SNARE binding activity; and arachidonate binding activity. Involved in exocytic insertion of neurotransmitter receptor to postsynaptic membrane; modulation of chemical synaptic transmission; and vesicle-mediated transport in synapse. Acts upstream of or within exocytosis and long-term synaptic potentiation. Located in several cellular components, including cytoplasmic vesicle; photoreceptor inner segment; and photoreceptor outer segment. Part of SNARE complex. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynapse. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human STX3 (syntaxin 3).

1 Names and Identifiers

1.1 Synonyms

  • Syn-3
  • syntaxin-3

1.1.1 MeSH Entry Terms

  • Qa-SNAREs
  • Syntaxin
  • Syntaxin 10
  • Syntaxin 3B Protein
  • Syntaxin 17
  • Syntaxin 3D Protein
  • Syntaxin 11 Protein
  • Syntaxin 18
  • Syntaxin 4
  • Syntaxin 3B
  • Syntaxin 5
  • Syntaxin 18 Protein
  • Syntaxin 3C Protein
  • Syntaxin 10 Protein
  • Syntaxin 1A Homologs
  • Syntaxin 11
  • Syntaxin 13
  • Syntaxin 3 Protein
  • Syntaxin 3D
  • Syntaxin 13 Protein
  • Syntaxin 4 Protein
  • Syntaxin 17 Protein
  • Syntaxin 3
  • Syntaxin 7
  • Syntaxin 3A
  • Syntaxin 3A Protein
  • Syntaxin 3C
  • Syntaxin 8
  • Syntaxin 7 Protein
  • Syntaxin 5 Protein
  • Syntaxin 8 Protein
  • Syntaxin 6
  • Syntaxin Protein
  • Syntaxins
  • Syntaxin Proteins
  • Syntaxin 6 Protein

1.2 Other Identifiers

1.2.1 Ensembl ID

1.2.2 Alliance Gene ID

1.2.3 Bgee Gene ID

1.2.4 MGI ID

1.2.5 VEuPathDB ID

1.2.6 Wikidata

3 Proteins

3.1 Protein Function

Potentially involved in docking of synaptic vesicles at presynaptic active zones. Apical receptor involved in membrane fusion of apical vesicles (By similarity). Essential for survival of retinal photoreceetors (PMID: 33974130).

3.2 Protein Isoforms

Isoform
Isoform 3A
UniProt ID
RefSeq Accession
Isoform
Isoform 3B
UniProt ID
RefSeq Accession
Isoform
Isoform 3C
UniProt ID
RefSeq Accession
Isoform
Isoform 3D
UniProt ID
RefSeq Accession

3.3 Protein 3D Structures

3.3.1 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

3.4 Protein Targets

4 BioAssays

4.1 RNAi BioAssays

5 Interactions and Pathways

5.1 Interactions

5.2 Pathways

6 Expression

7 Literature

7.1 Consolidated References

7.2 NLM Curated PubMed Citations

7.3 Gene-Chemical Co-Occurrences in Literature

7.4 Gene-Gene Co-Occurrences in Literature

7.5 Gene-Disease Co-Occurrences in Literature

8 Patents

8.1 Gene-Chemical Co-Occurrences in Patents

8.2 Gene-Gene Co-Occurrences in Patents

8.3 Gene-Disease Co-Occurrences in Patents

9 Classification

9.1 MeSH Tree

9.2 Gene Ontology: Biological Process

9.3 Gene Ontology: Cellular Component

9.4 Gene Ontology: Molecular Function

10 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Medical Subject Headings (MeSH)
    LICENSE
    Works produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.
    https://www.nlm.nih.gov/copyright.html
  4. Alliance of Genome Resources
    LICENSE
    All annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
    https://www.alliancegenome.org/privacy-warranty-licensing
  5. BioGRID
    LICENSE
    The MIT License (MIT); Copyright Mike Tyers Lab
    https://wiki.thebiogrid.org/doku.php/terms_and_conditions
  6. STRING: functional protein association networks
  7. Mouse Genome Informatics (MGI)
    LICENSE
    MGI data and annotations are licensed under a Creative Commons Attribution 4.0 International License (CC-BY).
    https://www.informatics.jax.org/mgihome/other/copyright.shtml
  8. NCBI Gene Expression Omnibus (GEO)
  9. Swiss Institute of Bioinformatics Bgee
    LICENSE
    Creative Commons Zero license (CC0)
    https://www.bgee.org/about/
  10. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  11. VEuPathDB: The Eukaryotic Pathogen, Vector and Host Informatics Resource
    LICENSE
    All data on VEuPathDB websites are provided freely for public use.
    https://veupathdb.org/veupathdb/app/static-content/about.html
  12. Wikidata
  13. Gene Ontology (GO)
    LICENSE
    Gene Ontology Consortium data and data products are licensed under the Creative Commons Attribution 4.0 Unported License (https://creativecommons.org/licenses/by/4.0/legalcode)
    http://geneontology.org/docs/go-citation-policy/
  14. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
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