Shc3 - src homology 2 domain-containing transforming protein C3 (house mouse)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-29
Description
Predicted to enable phosphotyrosine residue binding activity and receptor tyrosine kinase binding activity. Acts upstream of or within glutamatergic synaptic transmission and learning or memory. Predicted to be located in synapse. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and liver and biliary system. Orthologous to human SHC3 (SHC adaptor protein 3).
- N-Shc
- Rai
- ShcC
- SHC-transforming protein 3
- SH2 domain protein C3
- SHC-transforming protein C
- neuronal Shc
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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