tmc-1 - Transmembrane channel-like protein 1 (Caenorhabditis elegans)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-02-02
Description
Please note that currently there is no data available in PubChem associated with tmc-1 - Transmembrane channel-like protein 1 (Caenorhabditis elegans). However, annotations from external sources are available.
Enables sodium channel activity. Involved in detection of stimulus involved in sensory perception; monoatomic ion transmembrane transport; and sensory perception of chemical stimulus. Located in neuronal cell body; non-motile cilium; and plasma membrane. Is expressed in body wall musculature; neurons; vulval muscle; and in male. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 36; autosomal recessive nonsyndromic deafness 7; and sensorineural hearing loss. Orthologous to several human genes including TMC3 (transmembrane channel like 3).
Pore-forming subunit of the mechanotransducer (MET) non-selective cation channel complex (PMID: 36224384). The MET complex is composed of symmetric dimeric MET channels, each channel comprising two copies of pore-forming ion-conducting transmembrane TMC subunits and auxiliary proteins including the transmembrane inner ear protein/tmie, the calcium-binding protein/calm-1 and arrestin domain protein arrd-6 (PMID: 36224384). Sodium ions are the most permeable, whereas calcium and potassium have lower indices (PMID: 23364694). Sodium-sensor ion channel that acts specifically in salt taste chemosensation. Required for salt-evoked neuronal activity and behavioral avoidance of high concentrations of NaCl.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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