fmi-1 - Cadherin EGF LAG seven-pass G-type receptor fmi-1 (Caenorhabditis elegans)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-02-01
Description
Please note that currently there is no data available in PubChem associated with fmi-1 - Cadherin EGF LAG seven-pass G-type receptor fmi-1 (Caenorhabditis elegans). However, annotations from external sources are available.
Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Involved in anterior/posterior axon guidance and interneuron axon guidance. Located in axon. Is expressed in nervous system. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to several human genes including CELSR2 (cadherin EGF LAG seven-pass G-type receptor 2).
During ventral cord development, required for axon fasciculation and navigation, mediating both pioneer and follower axon extension, guidance and track formation (PMID: 20876647, PMID: 22442082, PMID: 23376536, PMID: 28846083). Acts in CEPsh glia and SubL neurons to guide follower axons into the nerve ring (PMID: 28846083). Promotes motorneuron development by positively regulating the extension of the anterior neurite of ventral D-type GABAergic motorneurons along the anterior-posterior axis of the ventral nerve cord (PMID: 23376536). Plays a role in synaptogenesis by regulating synaptic vesicle accumulation at GABAergic and cholinergic neuromuscular junctions (PMID: 22442082).
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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