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fmi-1 - Cadherin EGF LAG seven-pass G-type receptor fmi-1 (Caenorhabditis elegans)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-02-02
Description
Please note that currently there is no data available in PubChem associated with fmi-1 - Cadherin EGF LAG seven-pass G-type receptor fmi-1 (Caenorhabditis elegans). However, annotations from external sources are available.
Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Involved in anterior/posterior axon guidance and interneuron axon guidance. Located in axon. Is expressed in nervous system. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to several human genes including CELSR2 (cadherin EGF LAG seven-pass G-type receptor 2).

1 Names and Identifiers

1.1 Other Identifiers

1.1.1 Alliance Gene ID

1.1.2 Bgee Gene ID

1.1.3 Wikidata

1.1.4 WormBase ID

2 Proteins

2.1 Protein Function

During ventral cord development, required for axon fasciculation and navigation, mediating both pioneer and follower axon extension, guidance and track formation (PMID: 20876647, PMID: 22442082, PMID: 23376536, PMID: 28846083). Acts in CEPsh glia and SubL neurons to guide follower axons into the nerve ring (PMID: 28846083). Promotes motorneuron development by positively regulating the extension of the anterior neurite of ventral D-type GABAergic motorneurons along the anterior-posterior axis of the ventral nerve cord (PMID: 23376536). Plays a role in synaptogenesis by regulating synaptic vesicle accumulation at GABAergic and cholinergic neuromuscular junctions (PMID: 22442082).

2.2 Protein Isoforms

Isoform
Isoform a
UniProt ID
RefSeq Accession
Isoform
Isoform b
UniProt ID
RefSeq Accession
Isoform
Isoform c
UniProt ID
RefSeq Accession

2.3 Protein 3D Structures

2.3.1 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

2.4 Protein Targets

3 Interactions and Pathways

3.1 Chemical-Gene Interactions

3.2 Interactions

4 Literature

4.1 Consolidated References

4.2 Gene-Chemical Co-Occurrences in Literature

4.3 Gene-Gene Co-Occurrences in Literature

5 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Alliance of Genome Resources
    LICENSE
    All annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
    https://www.alliancegenome.org/privacy-warranty-licensing
  4. BioGRID
    LICENSE
    The MIT License (MIT); Copyright Mike Tyers Lab
    https://wiki.thebiogrid.org/doku.php/terms_and_conditions
  5. Comparative Toxicogenomics Database (CTD)
    LICENSE
    It is to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of NC State University.
    http://ctdbase.org/about/legal.jsp
  6. Swiss Institute of Bioinformatics Bgee
    LICENSE
    Creative Commons Zero license (CC0)
    https://www.bgee.org/about/
  7. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  8. Wikidata
  9. WormBase
  10. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
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