itr-1 - Inositol 1,4,5-trisphosphate receptor itr-1 (Caenorhabditis elegans)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-17
Description
Enables myosin binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of nematode pharyngeal pumping; and sperm ejaculation. Located in endoplasmic reticulum and membrane. Is expressed in several structures, including epithelial cell; ganglia; gonad; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including Gillespie syndrome; amyotrophic lateral sclerosis; autosomal dominant cerebellar ataxia (multiple); isolated anhidrosis with normal sweat glands; and type 1 diabetes mellitus. Orthologous to human ITPR1 (inositol 1,4,5-trisphosphate receptor type 1); ITPR2 (inositol 1,4,5-trisphosphate receptor type 2); and ITPR3 (inositol 1,4,5-trisphosphate receptor type 3).
Receptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis (PMID: 10499793, PMID: 10610772, PMID: 15194811, PMID: 16186564, PMID: 23671426). Binds in vitro to both inositol 1,4,5-trisphosphate (1,4,5-InsP3) and inositol 2,4,5-trisphosphate (2,4,5-InsP3) with high affinity and does not discriminate between the phosphate at 1 or 2 position (PMID: 10610772). Can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity (PMID: 10610772). Acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyngeal pumping (PMID: 10499793, PMID: 11553721, PMID: 11950942, PMID: 12062062, PMID: 15013747, PMID: 15133127, PMID: 16186564, PMID: 21191812). Affects normal hermaphrodite and male fertility as a participant in intracellular signaling by acting downstream of let-23/lin-3 which regulates ovulation, spermathecal valve dilation and male mating behavior (PMID: 15194811, PMID: 15958491, PMID: 16267094, PMID: 9491893). Important for early embryonic development; controls epidermal cell migration and may also regulate filopodial protrusive activity during epithelial morphogenesis (PMID: 11950942, PMID: 15498499, PMID: 18369461). Component of inositol trisphosphate (IP3)-mediated downstream signaling pathways that controls amphid sensory neuronal (ASH)-mediated response to nose touch and benzaldehyde but not other ASH-mediated responses (PMID: 19730689). Involved in modulating lifespan, acting downstream of transcription factor atf-6 (PMID: 32905769).
Isoform
UniProt ID
RefSeq Accession
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