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itr-1 - Inositol 1,4,5-trisphosphate receptor itr-1 (Caenorhabditis elegans)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-17
Description
Enables myosin binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of nematode pharyngeal pumping; and sperm ejaculation. Located in endoplasmic reticulum and membrane. Is expressed in several structures, including epithelial cell; ganglia; gonad; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including Gillespie syndrome; amyotrophic lateral sclerosis; autosomal dominant cerebellar ataxia (multiple); isolated anhidrosis with normal sweat glands; and type 1 diabetes mellitus. Orthologous to human ITPR1 (inositol 1,4,5-trisphosphate receptor type 1); ITPR2 (inositol 1,4,5-trisphosphate receptor type 2); and ITPR3 (inositol 1,4,5-trisphosphate receptor type 3).

1 Names and Identifiers

1.1 Other Identifiers

1.1.1 Alliance Gene ID

1.1.2 Bgee Gene ID

1.1.3 Wikidata

1.1.4 WormBase ID

2 Proteins

2.1 Protein Function

Receptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis (PMID: 10499793, PMID: 10610772, PMID: 15194811, PMID: 16186564, PMID: 23671426). Binds in vitro to both inositol 1,4,5-trisphosphate (1,4,5-InsP3) and inositol 2,4,5-trisphosphate (2,4,5-InsP3) with high affinity and does not discriminate between the phosphate at 1 or 2 position (PMID: 10610772). Can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity (PMID: 10610772). Acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyngeal pumping (PMID: 10499793, PMID: 11553721, PMID: 11950942, PMID: 12062062, PMID: 15013747, PMID: 15133127, PMID: 16186564, PMID: 21191812). Affects normal hermaphrodite and male fertility as a participant in intracellular signaling by acting downstream of let-23/lin-3 which regulates ovulation, spermathecal valve dilation and male mating behavior (PMID: 15194811, PMID: 15958491, PMID: 16267094, PMID: 9491893). Important for early embryonic development; controls epidermal cell migration and may also regulate filopodial protrusive activity during epithelial morphogenesis (PMID: 11950942, PMID: 15498499, PMID: 18369461). Component of inositol trisphosphate (IP3)-mediated downstream signaling pathways that controls amphid sensory neuronal (ASH)-mediated response to nose touch and benzaldehyde but not other ASH-mediated responses (PMID: 19730689). Involved in modulating lifespan, acting downstream of transcription factor atf-6 (PMID: 32905769).

2.2 Protein Isoforms

Isoform
Isoform a
UniProt ID
RefSeq Accession
Isoform
Isoform d
UniProt ID
RefSeq Accession
Isoform
Isoform e
UniProt ID
RefSeq Accession
Isoform
Isoform f
UniProt ID
RefSeq Accession
Isoform
Isoform g
UniProt ID
RefSeq Accession
Isoform
Isoform h
UniProt ID
RefSeq Accession

2.3 Protein Targets

3 Interactions and Pathways

3.1 Chemical-Gene Interactions

3.2 Interactions

3.3 Pathways

4 Biochemical Reactions

5 Expression

6 Literature

6.1 Consolidated References

6.2 Gene-Chemical Co-Occurrences in Literature

6.3 Gene-Gene Co-Occurrences in Literature

6.4 Gene-Disease Co-Occurrences in Literature

7 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Alliance of Genome Resources
    LICENSE
    All annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
    https://www.alliancegenome.org/privacy-warranty-licensing
  4. BioGRID
    LICENSE
    The MIT License (MIT); Copyright Mike Tyers Lab
    https://wiki.thebiogrid.org/doku.php/terms_and_conditions
  5. STRING: functional protein association networks
  6. Comparative Toxicogenomics Database (CTD)
    LICENSE
    It is to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of NC State University.
    http://ctdbase.org/about/legal.jsp
  7. NCBI Gene Expression Omnibus (GEO)
  8. Swiss Institute of Bioinformatics Bgee
    LICENSE
    Creative Commons Zero license (CC0)
    https://www.bgee.org/about/
  9. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  10. Wikidata
  11. WormBase
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