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daf-4 - Cell surface receptor daf-4;Serine/threonine-protein kinase receptor;receptor protein serine/threonine kinase (Caenorhabditis elegans)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-18
Description
Enables BMP binding activity. Involved in several processes, including dauer entry; defense response to other organism; and regulation of BMP signaling pathway. Located in plasma membrane. Is expressed in several structures, including ganglia; intestine; somatic nervous system; tail hypodermis; and vulva. Used to study Marfan syndrome. Human ortholog(s) of this gene implicated in several diseases, including Loeys-Dietz syndrome 2; Lynch syndrome (multiple); Marfan syndrome; gastrointestinal system cancer (multiple); and mismatch repair cancer syndrome. Orthologous to several human genes including ACVR2B (activin A receptor type 2B).

1 Names and Identifiers

1.1 Other Identifiers

1.1.1 Alliance Gene ID

1.1.2 Bgee Gene ID

1.1.3 Enzyme Commission (EC) Number

1.1.4 Wikidata

1.1.5 WormBase ID

2 Proteins

2.1 Protein Function

Involved in a TGF-beta pathway (PMID: 8413626). May be a receptor for TGF-beta-like ligand daf-7 (PMID: 8413626). Controls the decision of whether or not larvae enter a developmentally arrested state, known as dauer, in response to environmental conditions (PMID: 8413626). Regulates body size and male tail patterning (PMID: 10887089, PMID: 21408209). Involved in regulating entry into quiescence triggered by satiety (PMID: 18316030). Involved in sensitivity to CO2 levels (PMID: 18524955).

2.2 Protein 3D Structures

2.2.1 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

2.3 Protein Targets

3 Interactions and Pathways

3.1 Interactions

3.2 Pathways

4 Biochemical Reactions

5 Expression

6 Literature

6.1 Consolidated References

6.2 Gene-Chemical Co-Occurrences in Literature

6.3 Gene-Gene Co-Occurrences in Literature

6.4 Gene-Disease Co-Occurrences in Literature

7 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Alliance of Genome Resources
    LICENSE
    All annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
    https://www.alliancegenome.org/privacy-warranty-licensing
  4. BioGRID
    LICENSE
    The MIT License (MIT); Copyright Mike Tyers Lab
    https://wiki.thebiogrid.org/doku.php/terms_and_conditions
  5. STRING: functional protein association networks
  6. NCBI Gene Expression Omnibus (GEO)
  7. Swiss Institute of Bioinformatics Bgee
    LICENSE
    Creative Commons Zero license (CC0)
    https://www.bgee.org/about/
  8. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  9. Wikidata
  10. WormBase
  11. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
  12. Rhea - annotated reactions database
    LICENSE
    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
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