daf-4 - Cell surface receptor daf-4;Serine/threonine-protein kinase receptor;receptor protein serine/threonine kinase (Caenorhabditis elegans)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-18
Description
Enables BMP binding activity. Involved in several processes, including dauer entry; defense response to other organism; and regulation of BMP signaling pathway. Located in plasma membrane. Is expressed in several structures, including ganglia; intestine; somatic nervous system; tail hypodermis; and vulva. Used to study Marfan syndrome. Human ortholog(s) of this gene implicated in several diseases, including Loeys-Dietz syndrome 2; Lynch syndrome (multiple); Marfan syndrome; gastrointestinal system cancer (multiple); and mismatch repair cancer syndrome. Orthologous to several human genes including ACVR2B (activin A receptor type 2B).
Involved in a TGF-beta pathway (PMID: 8413626). May be a receptor for TGF-beta-like ligand daf-7 (PMID: 8413626). Controls the decision of whether or not larvae enter a developmentally arrested state, known as dauer, in response to environmental conditions (PMID: 8413626). Regulates body size and male tail patterning (PMID: 10887089, PMID: 21408209). Involved in regulating entry into quiescence triggered by satiety (PMID: 18316030). Involved in sensitivity to CO2 levels (PMID: 18524955).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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