Foxc2 - forkhead box C2 (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-18
Description
Enables DNA binding activity. Predicted to be involved in several processes, including insulin receptor signaling pathway; negative regulation of cold-induced thermogenesis; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including cell surface receptor signaling pathway; circulatory system development; and kidney development. Predicted to be located in nuclear body. Human ortholog(s) of this gene implicated in several diseases, including lymphedema; lymphedema-distichiasis syndrome; obesity; ptosis; and type 2 diabetes mellitus. Orthologous to human FOXC2 (forkhead box C2).
- Fkh14
- Fkhl14
- Hfhbf3
- forkhead box protein C2
- BF-3
- HFH-BF-3
- brain factor 3
- forkhead box C2 (MFH-1, mesenchyme forkhead 1)
Transcriptional activator.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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- NCBI Gene Expression Omnibus (GEO)
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- STRING: functional protein association networks
- Swiss Institute of Bioinformatics Bgee
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