Cd209c - CD209c antigen (house mouse)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-02-01
Description
Enables D-mannose binding activity. Predicted to be involved in several processes, including B cell adhesion; positive regulation of T cell proliferation; and positive regulation of viral life cycle. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in Coronavirus infectious disease; aspergillosis; dengue disease (multiple); human immunodeficiency virus infectious disease (multiple); and tuberculosis (multiple). Orthologous to human CD209 (CD209 molecule).
- SIGNR2
- mSIGNR2
- CD209 antigen-like protein C
- DC-SIGN-related protein 2
- DC-SIGNR2
Probable pathogen-recognition receptor. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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