Parvb - parvin, beta (house mouse)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-02-01
Description
Predicted to enable actin binding activity. Predicted to be involved in several processes, including establishment or maintenance of cell polarity regulating cell shape; lamellipodium assembly; and substrate adhesion-dependent cell spreading. Predicted to be located in cytosol. Predicted to be active in several cellular components, including actin cytoskeleton; focal adhesion; and lamellipodium. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; liver; and sensory organ. Orthologous to human PARVB (parvin beta).
- D15Gsk1
- affixin
- beta-parvin
Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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