Tas1r3 - taste 1 receptor member 3 (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-15
Description
Enables taste receptor activity. Involved in sensory perception of sweet taste and sensory perception of umami taste. Predicted to be located in Golgi apparatus. Predicted to be part of sweet taste receptor complex. Predicted to be active in plasma membrane. Orthologous to human TAS1R3 (taste 1 receptor member 3).
- T1r3
- taste receptor type 1 member 3
- sweet taste receptor T1R3
- taste receptor, type 1, member 3
Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) and also to most of the 20 standard L-amino acids, but not to their D-enantiomers or other compounds. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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