CLEC4C - C-type lectin domain family 4 member C (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-29
Description
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Predicted to enable carbohydrate binding activity and pattern recognition receptor activity. Predicted to be involved in antifungal innate immune response. Predicted to act upstream of or within positive regulation of release of sequestered calcium ion into cytosol. Predicted to be located in ficolin-1-rich granule membrane; plasma membrane; and tertiary granule membrane. Predicted to be active in external side of plasma membrane.
- BDCA-2
- BDCA2
- CD303
- CLECSF11
- CLECSF7
- DLEC
- HECL
- PRO34150
- C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 11
- C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 7
- C-type lectin superfamily member 7
- blood dendritic cell antigen 2 protein
- dendritic cell lectin b
- dendritic lectin
Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells (PMID: 11748283, PMID: 21880719, PMID: 25995448). Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man (PMID: 21880719, PMID: 25995448). Binds to serum IgG (PMID: 25995448). Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells (PMID: 11748283). May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells (PMID: 11748283, PMID: 21880719). May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium (PMID: 11748283).
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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