CFD - complement factor D (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-02-01
Description
This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease. [provided by RefSeq, Nov 2015]
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein maturation. Predicted to act upstream of or within several processes, including complement activation, alternative pathway; retina development in camera-type eye; and vascular associated smooth muscle cell differentiation. Located in extracellular exosome. Biomarker of obesity.
- ADIPSIN
- ADN
- DF
- PFD
- C3 convertase activator
- D component of complement (adipsin)
- complement factor D preproprotein
- properdin factor D
- 28 kDa Protein, Adipocyte
- Adipsin
- C3 Convertase Activator
- C3PA Convertase
- C3PAse
- C3 Proactivator Convertase
- Complement Protein D
- D Component of Complement
- Factor D
- GBGase
- Proactivator Convertase
- Properdin Factor D
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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