Gpr3 - G-protein coupled receptor 3 (house mouse)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-02-02
Description
Predicted to enable sphingosine-1-phosphate receptor activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within regulation of meiotic nuclear division. Predicted to be active in cytoplasm and plasma membrane. Is expressed in central nervous system; eye; gonad; and salivary gland. Orthologous to human GPR3 (G protein-coupled receptor 3).
- Gpcr20
- Gpcr21
- Gpcr3
Constitutively active G-protein coupled receptor that maintains high 3'-5'-cyclic adenosine monophosphate (cAMP) levels that a plays a role in serveral processes including meiotic arrest in oocytes or neuronal development via activation of numerous intracellular signaling pathways (PMID: 15956199, PMID: 19259266). Acts as an essential activator of thermogenic adipocytes and drives thermogenesis via its intrinsic G(s)-coupling activity without the requirement of a ligand (PMID: 26455425, PMID: 34048700). Has a potential role in modulating a number of brain functions, including behavioral responses to stress, amyloid-beta peptide generation in neurons. Stimulates neurite outgrowth in cerebellar granular neurons modulated via PKA, ERK, and most strongly PI3K-mediated signaling pathways (PMID: 34871769).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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