Tsc22d3 - TSC22 domain family, member 3 (house mouse)
- Create:2016-09-14
- Modify:2025-02-02
- DIP
- Dsip1
- Gilz
- TSC-22R
- Tilz3
- TSC22 domain family protein 3
- TSC22-related inducible leucine zipper 3
- delta sleep inducing peptide, immunoreactor
- glucocorticoid-induced leucine zipper protein
- long glucocorticoid-induced leucine zipper protein
Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11 (PMID: 26752201). In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10 (By similarity). In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation and thereby NFKB1 DNA-binding activities (By similarity). In vitro, suppresses AP-1 transcription factor complex DNA-binding activities (PMID: 11397794).
Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG.
Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG.
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