Cxcr4 - C-X-C motif chemokine receptor 4 (house mouse)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-27
Description
Predicted to enable several functions, including chemokine receptor activity; cytoskeletal protein binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including nervous system development; positive regulation of cold-induced thermogenesis; and positive regulation of oligodendrocyte differentiation. Acts upstream of or within several processes, including CXCL12-activated CXCR4 signaling pathway; circulatory system development; and nervous system development. Located in cell-cell junction; external side of plasma membrane; and growth cone. Is expressed in several structures, including alimentary system; cardiovascular system; embryo mesenchyme; extraembryonic component; and nervous system. Used to study WHIM syndrome 1; cardiomyopathy; and congestive heart failure. Human ortholog(s) of this gene implicated in several diseases, including WHIM syndrome 1; bone disease (multiple); hematologic cancer (multiple); pancreatic adenocarcinoma; and prostate cancer. Orthologous to human CXCR4 (C-X-C motif chemokine receptor 4).
- CD184
- CXC-R4
- CXCR-4
- Cmkar4
- LESTR
- PB-CKR
- PBSF/SDF-1
- Sdf1r
- b2b220Clo
- C-X-C chemokine receptor type 4
- SDF-1 receptor
- chemokine (C-X-C motif) receptor 4
- chemokine (C-X-C) receptor 4
- chemokine receptor 4
- fusin
- leukocyte-derived seven transmembrane domain receptor
- leukocyte-expressed seven-transmembrane-domain
- pre-B-cell-derived chemokine receptor
- stromal cell-derived factor 1 receptor
- CXC Chemokine Receptor 4
- CXCR4 Receptor
- CXCR4 Receptors
- Fusin
- LESTR Receptor
- Leukocyte-Derived Seven-Transmembrane Domain Receptor
- Receptor, LESTR
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PMID: 8962122, PMID: 9103415, PMID: 9295051). Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation (PMID: 9634237, PMID: 9634238, PMID: 9689100). Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells (PMID: 9634237). Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (PMID: 9634238, PMID: 9689100).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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