Atp2b2 - ATPase, Ca++ transporting, plasma membrane 2 (house mouse)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-29
Description
Enables calcium-dependent ATPase activity. Involved in calcium ion transport; cochlea development; and regulation of cytosolic calcium ion concentration. Acts upstream of or within several processes, including detection of mechanical stimulus involved in sensory perception of sound; lactation; and neuron differentiation. Located in several cellular components, including apical plasma membrane; endoplasmic reticulum; and neuronal cell body. Is active in glutamatergic synapse; photoreceptor ribbon synapse; and presynaptic membrane. Is expressed in heart; labyrinthine zone; liver; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 82 and autosomal recessive nonsyndromic deafness 12. Orthologous to human ATP2B2 (ATPase plasma membrane Ca2+ transporting 2).
- D6Abb2e
- Gena300
- PMCA2
- Tmy
- dfw
- jog
- wms
- wri
- plasma membrane calcium-transporting ATPase 2
- deaf waddler
- plasma membrane calcium ATPase
- plasma membrane calcium pump
- wriggle
- Calcium-Transporting ATPases, Plasma Membrane
- PMCA2 Calcium-Transporting ATPase
- PMCA Calcium-Transporting ATPases
- PMCA1 Calcium-Transporting ATPase
- PMCA4 Calcium-Transporting ATPase
- PMCA3 Calcium-Transporting ATPase
- Plasma Membrane Calcium-Transporting ATPase 1
- Plasma Membrane Calcium-Transporting ATPase 2
- Plasma Membrane Ca(2+)-Pumping Adenosinetriphosphatase
- Plasma Membrane Calcium ATPase
- Plasma Membrane Calcium-Transporting ATPase 3
- Plasma Membrane Calcium-Transporting ATPase 4
ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PMID: 17234811, PMID: 9668038). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment. Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics (PMID: 17409239, PMID: 20083513). At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (PMID: 17409239, PMID: 20083513). Plays an essential role in hearing and balance. In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (By similarity) (PMID: 9668038). Regulates Ca(2+) signaling through dissipation of Ca(2+) transients generated by store-operated channels (By similarity). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (PMID: 15302868).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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