Pip4k2a - phosphatidylinositol-5-phosphate 4-kinase type 2 alpha (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-18
Description
Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; and protein homodimerization activity. Predicted to be involved in several processes, including 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; autophagosome-lysosome fusion; and megakaryocyte development. Predicted to be located in autophagosome; cytosol; and lysosome. Predicted to be active in plasma membrane. Orthologous to human PIP4K2A (phosphatidylinositol-5-phosphate 4-kinase type 2 alpha).
- Pip5k2a
- phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
- 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha
- 1-phosphatidylinositol-5-phosphate 4-kinase A
- PI(5)P 4-kinase type II alpha
- PIP4KII-alpha
- PIPK2 alpha
- diphosphoinositide kinase 2-alpha
- phosphatidylinositol 5-phosphate 4-kinase type II alpha
- phosphatidylinositol-4-phosphate 5-kinase, type II, alpha
- phosphatidylinositol-5-phosphate 4-kinase type-2 alpha-like
- PIP4K2A (human)
- PIP4K2A (black-footed ferret)
- PIP4K2A (European mink)
- PIP4K2A (Ahaetulla prasina)
- PIP4K2A (red-backed fairy wren)
- PIP4K2A (Oenanthe melanoleuca)
- PIP4K2A (Chinese forest musk deer)
- PIP4K2A (raccoon dog)
- PIP4K2A (Leopard gecko)
- PIP4K2A (Pteronotus mesoamericanus)
- PIP4K2A (black-legged kittiwake)
- PIP4K2A (Aeolian wall lizard)
- PIP4K2A (graceful crag lizard)
- PIP4K2A (lesser prairie-chicken)
- PIP4K2A (takin)
- PIP4K2A (yellow-footed antechinus)
- PIP4K2A (California condor)
- PIP4K2A (Macaca thibetana thibetana)
- PIP4K2A (Northern goshawk)
- PIP4K2A (snow leopard)
- PIP4K2A (rock ptarmigan)
- PIP4K2A (Loggerhead turtle)
- PIP4K2A (Sphaerodactylus townsendi)
- PIP4K2A (Eurasian river otter)
- PIP4K2A (bobcat)
- PIP4K2A (greater spear-nosed bat)
- PIP4K2A (American black bear)
- PIP4K2A (Ring-tailed lemur)
- PIP4K2A (Agile Gracile Mouse Opossum)
- PIP4K2A (Komodo dragon)
- PIP4K2A (American mink)
- PIP4K2A (leopard cat)
- PIP4K2A (wapiti)
- PIP4K2A (fence lizard)
- PIP4K2A (Arctic fox)
- PIP4K2A (rufous-necked snowfinch)
- PIP4K2A (white-rumped snowfinch)
- PIP4K2A (jaguarundi)
- PIP4K2A (common toad)
- PIP4K2A (common frog)
- PIP4K2A (scimitar-horned oryx)
- PIP4K2A (Barn swallow)
- PIP4K2A (large flying fox)
- PIP4K2A (Eurasian tree sparrow)
- PIP4K2A (Reeves's turtle)
- PIP4K2A (Tiger rattlesnake)
- PIP4K2A (striped hyena)
- PIP4K2A (leatherback sea turtle)
- PIP4K2A (Iberian mole)
- PIP4K2A (Jamaican fruit-eating bat)
- PIP4K2A (Sturnira hondurensis)
- PIP4K2A (Kuhl's pipistrelle)
- PIP4K2A (Myotis myotis)
- PIP4K2A (Pallas's mastiff bat)
- PIP4K2A (black swan)
- PIP4K2A (common lizard)
- PIP4K2A (Southern elephant seal)
- PIP4K2A (Trachemys scripta elegans)
- PIP4K2A (Pantherophis guttatus)
- PIP4K2A (Gaboon caecilian)
- PIP4K2A (Francois's langur)
- PIP4K2A (greater horseshoe bat)
- PIP4K2A (sea lamprey)
- PIP4K2A (Abingdon island giant tortoise)
- PIP4K2A (vaquita)
- PIP4K2A (tufted duck)
- PIP4K2A (silvery gibbon)
- PIP4K2A (ring-necked pheasant)
- PIP4K2A (Kakapo)
- PIP4K2A (Microcaecilia unicolor)
- PIP4K2A (Aquila chrysaetos chrysaetos)
- PIP4K2A (Common wall lizard)
- PIP4K2A (pale spear-nosed bat)
- PIP4K2A (Steller sea lion)
- PIP4K2A (willow flycatcher)
- PIP4K2A (California sea lion)
- PIP4K2A (burrowing owl)
- PIP4K2A (eastern brown snake)
- PIP4K2A (mainland tiger snake)
- PIP4K2A (brown bear)
- PIP4K2A (emu)
- PIP4K2A (Okarito brown kiwi)
- PIP4K2A (Nothoprocta perdicaria)
- PIP4K2A (red fox)
- PIP4K2A (puma)
- PIP4K2A (dingo)
- PIP4K2A (gelada)
- PIP4K2A (Yangtze finless porpoise)
- PIP4K2A (common vampire bat)
- PIP4K2A (blue tit)
- PIP4K2A (Ugandan red Colobus)
- PIP4K2A (beluga whale)
- PIP4K2A (Hawaiian monk seal)
- PIP4K2A (white-rumped munia)
- PIP4K2A (helmeted guineafowl)
- PIP4K2A (koala)
- PIP4K2A (central bearded dragon)
- PIP4K2A (zebu cattle)
- PIP4K2A (Australian saltwater crocodile)
- PIP4K2A (Gharial)
- PIP4K2A (leopard)
- PIP4K2A (Nanorana parkeri)
- PIP4K2A (black snub-nosed monkey)
- PIP4K2A (Malayan pangolin)
- PIP4K2A (Panamanian white-faced capuchin)
- PIP4K2A (Miniopterus natalensis)
- PIP4K2A (Egyptian rousette)
- PIP4K2A (Japanese quail)
- PIP4K2A (Taiwan habu)
- PIP4K2A (Great Tit)
- PIP4K2A (Gekko japonicus)
- PIP4K2A (cheetah)
- PIP4K2A (Common starling)
- PIP4K2A (ass)
- PIP4K2A (Thamnophis sirtalis)
- PIP4K2A (North Island brown kiwi)
- PIP4K2A (Swan goose)
- PIP4K2A (gray mouse lemur)
- PIP4K2A (Coquerel's sifaka)
- PIP4K2A (sooty mangabey)
- PIP4K2A (drill)
- PIP4K2A (Colobus angolensis palliatus)
- PIP4K2A (pig-tailed macaque)
- PIP4K2A (large flying fox)
- PIP4K2A (Arabian camel)
- PIP4K2A (Bactrian camel)
- PIP4K2A (Bison bison bison)
- PIP4K2A (bald eagle)
- PIP4K2A (Corvus cornix cornix)
- PIP4K2A (golden snub-nosed monkey)
- PIP4K2A (East African grey crowned-crane)
- PIP4K2A (white-throated tinamou)
- PIP4K2A (speckled mousebird)
- PIP4K2A (chuck-will's-widow)
- PIP4K2A (Buceros rhinoceros silvestris)
- PIP4K2A (yellow-throated sandgrouse)
- PIP4K2A (chimney swift)
- PIP4K2A (common barn owl)
- PIP4K2A (cuckoo roller)
- PIP4K2A (hoatzin)
- PIP4K2A (Downy woodpecker)
- PIP4K2A (killdeer)
- PIP4K2A (bar-tailed trogon)
- PIP4K2A (red-throated loon)
- PIP4K2A (Red-legged seriema)
- PIP4K2A (African ostrich)
- PIP4K2A (little egret)
- PIP4K2A (Northern fulmar)
- PIP4K2A (common cuckoo)
- PIP4K2A (great cormorant)
- PIP4K2A (Dalmatian pelican)
- PIP4K2A (crested ibis)
- PIP4K2A (Adelie penguin)
- PIP4K2A (emperor penguin)
- PIP4K2A (Common canary)
- PIP4K2A (polar bear)
- PIP4K2A (American crow)
- PIP4K2A (Sunda flying lemur)
- PIP4K2A (Przewalski's horse)
- PIP4K2A (big brown bat)
- PIP4K2A (Philippine tarsier)
- PIP4K2A (green monkey)
- PIP4K2A (Yangtze River dolphin)
- PIP4K2A (Burmese python)
- PIP4K2A (minke whale)
- PIP4K2A (sperm whale)
- PIP4K2A (tiger)
- PIP4K2A (Green sea turtle)
- PIP4K2A (black flying fox)
- PIP4K2A (Myotis davidii)
- PIP4K2A (Weddell seal)
- PIP4K2A (American alligator)
- PIP4K2A (alpaca)
- PIP4K2A (Wild Bactrian camel)
- PIP4K2A (Chinese tree shrew)
- PIP4K2A (Chinese soft-shelled turtle)
- PIP4K2A (little brown bat)
- PIP4K2A (water buffalo)
- PIP4K2A (Chinese alligator)
- PIP4K2A (wild yak)
- PIP4K2A (Brandt's bat)
- PIP4K2A (goat)
- PIP4K2A (Tibetan ground-tit)
- PIP4K2A (rock pigeon)
- PIP4K2A (white-throated sparrow)
- PIP4K2A (Saker falcon)
- PIP4K2A (medium ground-finch)
- Pip4k2a (long-tailed chinchilla)
- PIP4K2A (western painted turtle)
- PIP4K2A (crab-eating macaque)
- PIP4K2A (peregrine falcon)
- PIP4K2A (Collared flycatcher)
- PIP4K2A (mallard)
- PIP4K2A (domestic ferret)
- PIP4K2A (small Madagascar hedgehog)
- PIP4K2A (European shrew)
- PIP4K2A (American pika)
- PIP4K2A (nine-banded armadillo)
- PIP4K2A (Pacific walrus)
- PIP4K2A (killer whale)
- PIP4K2A (western lowland gorilla)
- PIP4K2A (sheep)
- PIP4K2A (domestic cat)
- PIP4K2A (Bolivian squirrel monkey)
- PIP4K2A (olive baboon)
- PIP4K2A (pygmy chimpanzee)
- PIP4K2A (small-eared galago)
- PIP4K2A (Tasmanian devil)
- PIP4K2A (African savanna elephant)
- PIP4K2A (northern white-cheeked gibbon)
- PIP4K2A (turkey)
- PIP4K2A (pig)
- PIP4K2A (giant panda)
- PIP4K2A (Sumatran orangutan)
- PIP4K2A (white-tufted-ear marmoset)
- PIP4K2A (rabbit)
- PIP4K2A (zebra finch)
- pip4k2a (tropical clawed frog)
- PIP4K2A (platypus)
- PIP4K2A (horse)
- PIP4K2A (gray short-tailed opossum)
- PIP4K2A (chimpanzee)
- PIP4K2A (Rhesus monkey)
- PIP4K2A (dog)
- PIP4K2A (domestic cattle)
- PIP4K2A (chicken)
- Pip4k2a (house mouse)
Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Has both ATP- and GTP-dependent kinase activities. May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2 (By similarity). May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation (PMID: 20204506). Required for lysosome-peroxisome membrane contacts and intracellular cholesterol transport through modulating peroxisomal PtdIns(4,5)P2 level (By similarity). In collaboration with PIP4K2B, has a role in mediating autophagy in times of nutrient stress (By similarity). Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism (By similarity). Negatively regulates insulin signaling through a catalytic-independent mechanism. PIP4Ks interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PMID: 21847559). May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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