Kcnk4 - potassium two pore domain channel subfamily K member 4 (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-18
Description
Enables mechanosensitive potassium channel activity; potassium ion leak channel activity; and temperature-gated cation channel activity. Involved in several processes, including cellular response to alkaline pH; cellular response to temperature stimulus; and detection of mechanical stimulus involved in sensory perception of touch. Located in node of Ranvier and plasma membrane. Orthologous to human KCNK4 (potassium two pore domain channel subfamily K member 4).
- KT4.1
- TRAAK
- potassium channel subfamily K member 4
- TWIK-related arachidonic acid-stimulated potassium channel protein
- potassium channel, two pore domain subfamily K, member 4
- potassium inwardly-rectifying channel, subfamily K, member 4
K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, basic pH, heat and lipids (PMID: 11374070, PMID: 31630908). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (By similarity). At trigeminal A-beta afferent nerves, the heterodimer of KCNK2/TREK-1 and KCNK4/TRAAK is mostly coexpressed at nodes of Ranvier where it conducts voltage-independent mechanosensitive and thermosensitive currents, allowing rapid action potential repolarization, high speed and high frequence saltatory conduction on myelinated nerves to ensure prompt sensory responses (PMID: 31630908). Permeable to other monovalent cations such as Rb(+) and Cs(+) (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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