Ak2 - adenylate kinase 2 (house mouse)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-02-02
Description
Predicted to enable adenylate kinase activity. Predicted to contribute to nucleobase-containing compound kinase activity. Predicted to be involved in ADP biosynthetic process; AMP metabolic process; and dATP metabolic process. Located in sperm mitochondrial sheath. Is expressed in several structures, including alimentary system; brain; genitourinary system; musculoskeletal system; and sensory organ. Human ortholog(s) of this gene implicated in reticular dysgenesis. Orthologous to human AK2 (adenylate kinase 2).
- Ak-2
- D4Ertd220e
- adenylate kinase 2, mitochondrial
- AK 2
- ATP-AMP transphosphorylase 2
- ATP:AMP phosphotransferase
- adenylate monophosphate kinase
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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