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Prdx5 - peroxiredoxin 5 (Norway rat)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-18
Description
Predicted to enable several functions, including cysteine-type endopeptidase inhibitor activity involved in apoptotic process; identical protein binding activity; and peroxidase activity. Predicted to be involved in several processes, including NADPH oxidation; cell redox homeostasis; and regulation of apoptotic process. Located in mitochondrion and peroxisome. Orthologous to human PRDX5 (peroxiredoxin 5).

1 Names and Identifiers

1.1 Synonyms

  • Aoeb166
  • peroxiredoxin-5, mitochondrial
  • PLP
  • antioxidant enzyme B166
  • peroxiredoxin V
  • peroxisomal antioxidant enzyme
  • prx-V
  • thioredoxin peroxidase PMP20
  • thioredoxin reductase
  • thioredoxin-dependent peroxiredoxin 5

1.1.1 MeSH Entry Terms

  • Alkylhydroperoxide Reductase
  • Alkyl Hydroperoxide Reductase
  • Alkyl Hydroperoxide Reductase C
  • Alkyl Hydroperoxide Reductase D
  • Peroxidoxin
  • Peroxiredoxin I
  • Peroxiredoxin
  • Peroxiredoxin 4
  • Peroxiredoxin IV
  • Peroxiredoxin 5
  • Peroxiredoxin II
  • Peroxiredoxin V
  • Peroxiredoxin-4
  • Peroxiredoxin 1
  • Peroxiredoxin 2
  • Protector Protein (Mixed-Function Oxidase Systems)
  • Thiol-Specific Antioxidant Protein
  • Thioredoxin Peroxidase
  • Thioredoxin-Dependent Peroxide Reductase 1
  • Thioredoxin Peroxidase 2
  • Thioredoxin Peroxidase 1
  • Thioredoxin-Dependent Peroxide Reductase 2
  • Thioredoxin Peroxidase PMP20

1.2 Other Identifiers

1.2.1 Ensembl ID

1.2.2 Alliance Gene ID

1.2.3 RGD ID

1.2.4 Wikidata

3 Proteins

3.1 Protein Function

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.

3.2 Protein Isoforms

Isoform
Isoform Mitochondrial
UniProt ID
RefSeq Accession
Isoform
Isoform Cytoplasmic+peroxisomal
UniProt ID
RefSeq Accession

3.3 Protein 3D Structures

3.3.1 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

3.4 Protein Targets

4 Interactions and Pathways

4.1 Interactions

4.2 Pathways

5 Biochemical Reactions

6 Expression

7 Literature

7.1 Consolidated References

7.2 NLM Curated PubMed Citations

7.3 Gene-Chemical Co-Occurrences in Literature

7.4 Gene-Gene Co-Occurrences in Literature

7.5 Gene-Disease Co-Occurrences in Literature

8 Patents

8.1 Gene-Chemical Co-Occurrences in Patents

8.2 Gene-Gene Co-Occurrences in Patents

8.3 Gene-Disease Co-Occurrences in Patents

9 Classification

9.1 MeSH Tree

10 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Medical Subject Headings (MeSH)
    LICENSE
    Works produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.
    https://www.nlm.nih.gov/copyright.html
  4. Alliance of Genome Resources
    LICENSE
    All annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
    https://www.alliancegenome.org/privacy-warranty-licensing
  5. BioGRID
    LICENSE
    The MIT License (MIT); Copyright Mike Tyers Lab
    https://wiki.thebiogrid.org/doku.php/terms_and_conditions
  6. STRING: functional protein association networks
  7. NCBI Gene Expression Omnibus (GEO)
  8. Rat Genome Database (RGD)
    LICENSE
    Creative Commons Attribution 4.0 International license (CC BY 4.0)
    https://creativecommons.org/licenses/by/4.0/
  9. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  10. Wikidata
  11. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
  12. Rhea - annotated reactions database
    LICENSE
    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
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