CHIT1 - chitinase 1 (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-02
Description
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012]
Enables endochitinase activity. Involved in chitin catabolic process. Located in extracellular space.
- CHI3
- CHIT
- CHITD
- chitotriosidase-1
- chitinase 1 (chitotriosidase)
- plasma methylumbelliferyl tetra-N-acetylchitotetraoside hydrolase
- CHIT1 (black-footed ferret)
- CHIT1 (European mink)
- CHIT1 (Pteronotus mesoamericanus)
- CHIT1 (yellow-footed antechinus)
- CHIT1 (Macaca thibetana thibetana)
- CHIT1 (snow leopard)
- CHIT1 (bobcat)
- CHIT1 (American black bear)
- CHIT1 (Ring-tailed lemur)
- CHIT1 (American mink)
- CHIT1 (leopard cat)
- CHIT1 (wapiti)
- CHIT1 (Arctic fox)
- CHIT1 (jaguarundi)
- CHIT1 (scimitar-horned oryx)
- CHIT1 (striped hyena)
- CHIT1 (Kuhl's pipistrelle)
- CHIT1 (Myotis myotis)
- CHIT1 (Pallas's mastiff bat)
- CHIT1 (Southern elephant seal)
- CHIT1 (Francois's langur)
- CHIT1 (greater horseshoe bat)
- CHIT1 (vaquita)
- CHIT1 (silvery gibbon)
- CHIT1 (pale spear-nosed bat)
- CHIT1 (Steller sea lion)
- CHIT1 (California sea lion)
- CHIT1 (mainland tiger snake)
- CHIT1 (brown bear)
- CHIT1 (red fox)
- CHIT1 (puma)
- CHIT1 (gelada)
- CHIT1 (Yangtze finless porpoise)
- CHIT1 (Ugandan red Colobus)
- CHIT1 (beluga whale)
- CHIT1 (Hawaiian monk seal)
- CHIT1 (koala)
- CHIT1 (zebu cattle)
- CHIT1 (leopard)
- CHIT1 (black snub-nosed monkey)
- CHIT1 (Malayan pangolin)
- CHIT1 (Panamanian white-faced capuchin)
- CHIT1 (Miniopterus natalensis)
- CHIT1 (cheetah)
- CHIT1 (ass)
- CHIT1 (gray mouse lemur)
- CHIT1 (Coquerel's sifaka)
- CHIT1 (sooty mangabey)
- CHIT1 (drill)
- CHIT1 (Colobus angolensis palliatus)
- CHIT1 (pig-tailed macaque)
- CHIT1 (Arabian camel)
- CHIT1 (Bactrian camel)
- CHIT1 (Bison bison bison)
- CHIT1 (golden snub-nosed monkey)
- CHIT1 (polar bear)
- CHIT1 (Sunda flying lemur)
- CHIT1 (Przewalski's horse)
- CHIT1 (big brown bat)
- CHIT1 (Philippine tarsier)
- CHIT1 (green monkey)
- CHIT1 (Yangtze River dolphin)
- CHIT1 (minke whale)
- CHIT1 (sperm whale)
- CHIT1 (tiger)
- CHIT1 (Weddell seal)
- CHIT1 (alpaca)
- CHIT1 (Wild Bactrian camel)
- CHIT1 (Chinese tree shrew)
- CHIT1 (water buffalo)
- CHIT1 (Brandt's bat)
- CHIT1 (crab-eating macaque)
- Chit1 (long-tailed chinchilla)
- CHIT1 (domestic ferret)
- CHIT1 (small Madagascar hedgehog)
- CHIT1 (American pika)
- CHIT1 (nine-banded armadillo)
- CHIT1 (Pacific walrus)
- CHIT1 (killer whale)
- CHIT1 (western lowland gorilla)
- CHIT1 (domestic cat)
- CHIT1 (Bolivian squirrel monkey)
- CHIT1 (olive baboon)
- CHIT1 (pygmy chimpanzee)
- CHIT1 (small-eared galago)
- CHIT1 (Tasmanian devil)
- CHIT1 (African savanna elephant)
- CHIT1 (northern white-cheeked gibbon)
- CHIT1 (pig)
- CHIT1 (giant panda)
- CHIT1 (Sumatran orangutan)
- CHIT1 (white-tufted-ear marmoset)
- CHIT1 (rabbit)
- CHIT1 (platypus)
- CHIT1 (horse)
- CHIT1 (gray short-tailed opossum)
- CHIT1 (domestic cattle)
- CHIT1 (Rhesus monkey)
- CHIT1 (chimpanzee)
- Chit1 (Norway rat)
- Chit1 (house mouse)
Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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