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Eef1ece2 - Eef1akmt4-endothelin converting enzyme 2 readthrough (house mouse)

Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-17
Description
This locus represents naturally occurring readthrough transcription between the adjacent genes eukaryotic translation elongation factor 1 alpha lysine specific methyltransferase 4 (GeneID:110599566) and endothelin converting enzyme 2 (GeneID:107522). The readthrough transcript representing this gene encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Jul 2017]
Predicted to enable metalloendopeptidase activity. Predicted to be involved in brain development; cardioblast differentiation; and peptide hormone processing. Predicted to be located in Golgi membrane and transport vesicle membrane. Orthologous to human EEF1AKMT4-ECE2 (EEF1AKMT4-ECE2 readthrough) and ECE2 (endothelin converting enzyme 2).

1 Names and Identifiers

1.1 Synonyms

  • Eef1akmt4
  • Eef1akmt4-ece2
  • Gm49333
  • Eef1akmt4-Ece2 readthrough
  • EEF1A lysine methyltransferase 4
  • EEF1AKMT4-ECE2 readthrough transcript protein

1.2 Other Identifiers

1.2.1 Ensembl ID

1.2.2 Alliance Gene ID

1.2.3 Bgee Gene ID

1.2.4 Enzyme Commission (EC) Number

1.2.5 MGI ID

1.2.6 VEuPathDB ID

1.2.7 Wikidata

2 Proteins

2.1 Protein Function

Converts big endothelin-1 to endothelin-1. May also have methyltransferase activity (By similarity). May play a role in amyloid-beta processing (PMID: 12464614).
Protein-lysine methyltransferase that efficiently catalyzes three successive methylations on 'Lys-36' in eukaryotic translation elongation factor 1 alpha (EEF1A1 or EEF1A2).

2.2 Protein Isoforms

1 of 2
Isoform
Isoform Eef1akmt4-Ece2-1
UniProt ID
RefSeq Accession
Isoform
Isoform Eef1akmt4-Ece2-2
UniProt ID
RefSeq Accession
Isoform
Isoform Eef1akmt4-1
UniProt ID
RefSeq Accession
Isoform
Isoform Ece2-1
UniProt ID
RefSeq Accession
Isoform
Isoform Ece2-2
UniProt ID
RefSeq Accession
2 of 2
Isoform
Isoform Eef1akmt4-1
UniProt ID
RefSeq Accession
Isoform
Isoform Eef1akmt4-Ece2-1
UniProt ID
RefSeq Accession
Isoform
Isoform Eef1akmt4-Ece2-2
UniProt ID
RefSeq Accession

2.3 Protein 3D Structures

2.3.1 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

2.4 Protein Targets

3 Interactions and Pathways

3.1 Interactions

3.2 Pathways

4 Biochemical Reactions

5 Literature

5.1 Gene-Chemical Co-Occurrences in Literature

5.2 Gene-Gene Co-Occurrences in Literature

5.3 Gene-Disease Co-Occurrences in Literature

6 Patents

7 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Alliance of Genome Resources
    LICENSE
    All annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
    https://www.alliancegenome.org/privacy-warranty-licensing
  4. Mouse Genome Informatics (MGI)
    LICENSE
    MGI data and annotations are licensed under a Creative Commons Attribution 4.0 International License (CC-BY).
    https://www.informatics.jax.org/mgihome/other/copyright.shtml
  5. STRING: functional protein association networks
  6. Swiss Institute of Bioinformatics Bgee
    LICENSE
    Creative Commons Zero license (CC0)
    https://www.bgee.org/about/
  7. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  8. VEuPathDB: The Eukaryotic Pathogen, Vector and Host Informatics Resource
    LICENSE
    All data on VEuPathDB websites are provided freely for public use.
    https://veupathdb.org/veupathdb/app/static-content/about.html
  9. Wikidata
  10. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
  11. Rhea - annotated reactions database
    LICENSE
    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
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