Eef1ece2 - Eef1akmt4-endothelin converting enzyme 2 readthrough (house mouse)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-17
Description
This locus represents naturally occurring readthrough transcription between the adjacent genes eukaryotic translation elongation factor 1 alpha lysine specific methyltransferase 4 (GeneID:110599566) and endothelin converting enzyme 2 (GeneID:107522). The readthrough transcript representing this gene encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Jul 2017]
Predicted to enable metalloendopeptidase activity. Predicted to be involved in brain development; cardioblast differentiation; and peptide hormone processing. Predicted to be located in Golgi membrane and transport vesicle membrane. Orthologous to human EEF1AKMT4-ECE2 (EEF1AKMT4-ECE2 readthrough) and ECE2 (endothelin converting enzyme 2).
- Eef1akmt4
- Eef1akmt4-ece2
- Gm49333
- Eef1akmt4-Ece2 readthrough
- EEF1A lysine methyltransferase 4
- EEF1AKMT4-ECE2 readthrough transcript protein
Converts big endothelin-1 to endothelin-1. May also have methyltransferase activity (By similarity). May play a role in amyloid-beta processing (PMID: 12464614).
Protein-lysine methyltransferase that efficiently catalyzes three successive methylations on 'Lys-36' in eukaryotic translation elongation factor 1 alpha (EEF1A1 or EEF1A2).
Isoform
UniProt ID
RefSeq Accession
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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