SLC27A2 - solute carrier family 27 member 2 (human)
- Create:2016-09-14
- Modify:2025-01-18
- ACSVL1
- FACVL1
- FATP2
- HsT17226
- VLACS
- VLCS
- hFACVL1
- long-chain fatty acid transport protein 2
- FATP-2
- THCA-CoA ligase
- arachidonate--CoA ligase
- fatty acid transport protein 2
- fatty-acid-coenzyme A ligase, very long-chain 1
- long-chain-fatty-acid--CoA ligase
- phytanate--CoA ligase
- solute carrier family 27 (fatty acid transporter), member 2
- very long-chain acyl-CoA synthetase
- very long-chain fatty-acid-coenzyme A ligase 1
- very long-chain-fatty-acid-CoA ligase
- CoASH Ligase
- Fatty Acid Thiokinase (Long Chain)
- Nafenopin-CoA Ligase
- Palmitoyl CoA Synthetase
- Palmitoyl-CoA Synthase
- Palmityl CoA Synthetase
- Palmitoyl CoA Ligase
- Pristanoyl-CoA Synthetase
- VLACS Enzyme
- Very Long Chain Fatty Acid Acyl-CoA Synthetase
- Very Long-Chain Acyl-CoA Synthetase
- VLCFA Acyl-CoA Synthetase
Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes, playing an important role in hepatic fatty acid uptake (PMID: 10198260, PMID: 10749848, PMID: 11980911, PMID: 20530735, PMID: 22022213, PMID: 24269233). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (PMID: 10198260, PMID: 10749848, PMID: 11980911, PMID: 20530735, PMID: 22022213, PMID: 24269233). Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis (PMID: 20530735). Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid (PMID: 10198260). May contribute to the synthesis of sphingosine-1-phosphate (PMID: 24269233). Does not activate C24 bile acids, cholate and chenodeoxycholate (PMID: 11980911). In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (PMID: 11980911). However, it is not critical for THCA activation and bile synthesis in vivo (PMID: 20530735).
Exhibits both long-chain fatty acids (LCFA) transport activity and acyl CoA synthetase towards very long-chain fatty acids (PMID: 10198260, PMID: 21768100). Shows a preference for generating CoA derivatives of n-3 fatty acids, which are preferentially trafficked into phosphatidylinositol (PMID: 21768100).
Exhibits long-chain fatty acids (LCFA) transport activity but lacks acyl CoA synthetase towards very long-chain fatty acids.
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