An official website of the United States government

Ext1 - exostosin glycosyltransferase 1 (Chinese hamster)

Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-17
Description
Please note that currently there is no data available in PubChem associated with Ext1 - exostosin glycosyltransferase 1 (Chinese hamster). However, annotations from external sources are available.

1 Names and Identifiers

1.1 Synonyms

  • exostosin-1
  • Heparan sulfate copolymerase
  • Multiple exostoses protein 1 homolog
  • N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase
  • exostoses (multiple) 1
  • exostosin 1

1.1.1 MeSH Entry Terms

  • EXT1 Heparan Sulfate Copolymerase
  • Exostosin-1
  • Heparan Sulfate Copolymerase EXT1
  • Multiple Exostoses Protein 1

1.2 Other Identifiers

1.2.1 Ensembl ID

1.2.2 Enzyme Commission (EC) Number

1.2.3 GlyCosmos Gene

3 Proteins

3.1 Protein Function

Glycosyltransferase forming with EXT2 the heterodimeric heparan sulfate polymerase which catalyzes the elongation of the heparan sulfate glycan backbone. Glycan backbone extension consists in the alternating transfer of (1->4)-beta-D-GlcA and (1->4)-alpha-D-GlcNAc residues from their respective UDP-sugar donors. Both EXT1 and EXT2 are required for the full activity of the polymerase since EXT1 bears the N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity within the complex while EXT2 carries the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Heparan sulfate proteoglycans are ubiquitous components of the extracellular matrix and play an important role in tissue homeostasis and signaling.

3.2 Protein Targets

4 Biochemical Reactions

5 Literature

5.1 NLM Curated PubMed Citations

5.2 Gene-Chemical Co-Occurrences in Literature

5.3 Gene-Gene Co-Occurrences in Literature

5.4 Gene-Disease Co-Occurrences in Literature

6 Patents

6.1 Gene-Chemical Co-Occurrences in Patents

6.2 Gene-Gene Co-Occurrences in Patents

6.3 Gene-Disease Co-Occurrences in Patents

7 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Medical Subject Headings (MeSH)
    LICENSE
    Works produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.
    https://www.nlm.nih.gov/copyright.html
  4. GlyCosmos Glycoscience Portal
    LICENSE
    All copyrightable parts of the datasets in GlyCosmos are under the Creative Commons Attribution (CC BY 4.0) License.
    https://glycosmos.org/license
  5. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  6. Rhea - annotated reactions database
    LICENSE
    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
CONTENTS