Cobaltous 2-naphthenic acid
PubChem CID
14048876
Structure
Molecular Formula
Synonyms
- Cobalt naphthenate
- Cobaltous 2-naphthenic acid
- UNII-9M0814DLOU
- 9M0814DLOU
- 157583-32-9
Molecular Weight
401.3 g/mol
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Parent Compound
Component Compounds
Dates
- Create:2007-02-09
- Modify:2025-01-25
Description
Cobalt(II) naphthenate is a chemical compound of cobalt. It is used mainly as an oil drying agent. Cobalt is a metallic element with the atomic number 27. It is found naturally in rocks, soil, water, plants, and animals. In small amounts cobalt is an essential element for life, as it is part of vitamin B12. However, excess exposure is known to exhibit toxic effects. (L29, L30, L34)
L29: ATSDR - Agency for Toxic Substances and Disease Registry (2004). Toxicological profile for cobalt. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). http://www.atsdr.cdc.gov/toxprofiles/tp.asp?id=373&tid=64
L30: Wikipedia. Cobalt. Last Updated 21 March 2009. http://en.wikipedia.org/wiki/Cobalt
L34: Wikipedia. Cobalt(II) naphthenate. Last Updated 23 January 2009. http://en.wikipedia.org/wiki/Cobalt(II)_naphthenate
Chemical Structure Depiction
3D Conformer of Parent
cobalt(2+);naphthalene-2-carboxylate
Computed by Lexichem TK 2.7.0 (PubChem release 2021.10.14)
InChI=1S/2C11H8O2.Co/c2*12-11(13)10-6-5-8-3-1-2-4-9(8)7-10;/h2*1-7H,(H,12,13);/q;;+2/p-2
Computed by InChI 1.0.6 (PubChem release 2021.10.14)
IFSWBZCGMGEHLE-UHFFFAOYSA-L
Computed by InChI 1.0.6 (PubChem release 2021.10.14)
C1=CC=C2C=C(C=CC2=C1)C(=O)[O-].C1=CC=C2C=C(C=CC2=C1)C(=O)[O-].[Co+2]
Computed by OEChem 2.3.0 (PubChem release 2024.12.12)
C22H14CoO4
Computed by PubChem 2.2 (PubChem release 2021.10.14)
157583-32-9
61789-51-3
- cobalt naphthenate
- lead naphthenate
- naphthenic acid
- naphthenic acid, lead salt
- naphthenic acids
Property Name
Property Value
Reference
Property Name
Molecular Weight
Property Value
401.3 g/mol
Reference
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Property Name
Hydrogen Bond Donor Count
Property Value
0
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Hydrogen Bond Acceptor Count
Property Value
4
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Rotatable Bond Count
Property Value
0
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Exact Mass
Property Value
401.022402 Da
Reference
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Property Name
Monoisotopic Mass
Property Value
401.022402 Da
Reference
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Property Name
Topological Polar Surface Area
Property Value
80.3 Ų
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Heavy Atom Count
Property Value
27
Reference
Computed by PubChem
Property Name
Formal Charge
Property Value
0
Reference
Computed by PubChem
Property Name
Complexity
Property Value
195
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Isotope Atom Count
Property Value
0
Reference
Computed by PubChem
Property Name
Defined Atom Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Undefined Atom Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Defined Bond Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Undefined Bond Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Covalently-Bonded Unit Count
Property Value
3
Reference
Computed by PubChem
Property Name
Compound Is Canonicalized
Property Value
Yes
Reference
Computed by PubChem (release 2021.10.14)
Brown or blush-red solid; [ICSC] Insoluble in water; [MSDSonline]
BROWN AMORPHOUS OR BLUISH-RED SOLID.
140 °C
Solubility in water: none
0.9 g/cm³
276 °C
Metals -> Organic Acids, Metal Salts
Follow these links to do a live 2D search or do a live 3D search for this compound, sorted by annotation score. This section is deprecated (see here for details), but these live search links provide equivalent functionality to the table that was previously shown here.
Same Parent, Connectivity Count
Same Parent, Exact Count
Mixtures, Components, and Neutralized Forms Count
Similar Compounds (2D)
Similar Conformers (3D)
Same Count
Cobalt is absorbed though the lungs, gastrointestinal tract, and skin. Since it is a component of the vitamin B12 (cyanocobalamin), it is distributed to most tissues of the body. It is transported in the blood, often bound to albumin, with the highest levels being found in the liver and kidney. Cobalt is excreted mainly in the urine and faeces. (L29)
L29: ATSDR - Agency for Toxic Substances and Disease Registry (2004). Toxicological profile for cobalt. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). http://www.atsdr.cdc.gov/toxprofiles/tp.asp?id=373&tid=64
Sources/Uses
Used to make paints and varnishes; [CAMEO] Used as a curing agent in rubbers and resins; [Kanerva, p. 1772]
Kanerva - Rustemeyer L, Elsner P, John SM, Maibach HI (eds). Kanerva's Occupational Dermatology, 2nd Ed. Berlin: Springer-Verlag, 2012., p. 1772
Industrial Processes with risk of exposure
Painting (Pigments, Binders, and Biocides) [Category: Paint]
Cobalt(II) naphthenate is used mainly as an oil drying agent. (L34)
L34: Wikipedia. Cobalt(II) naphthenate. Last Updated 23 January 2009. http://en.wikipedia.org/wiki/Cobalt(II)_naphthenate
Hazard Classes and Categories -> Carcinogens, Flammable - 2nd degree
Household & Commercial/Institutional Products
Information on 8 consumer products that contain Cobalt naphthenate in the following categories is provided:
• Home Maintenance
• Inside the Home
Carcinogens, Flammable - 2nd degree
Gives off irritating or toxic fumes (or gases) in a fire. Finely dispersed particles form explosive mixtures in air.
An eye and respiratory tract irritant; May cause skin sensitization; [ICSC] See Lead naphthenate, Copper naphthenate, and Nickel naphthenate. See Cobalt.
Dust explosion possible if in powder or granular form, mixed with air.
Inhalation First Aid
Fresh air, rest. Refer for medical attention.
Skin First Aid
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .
Eye First Aid
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion First Aid
Rinse mouth. Refer for medical attention .
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Remove all ignition sources. Sweep spilled substance into sealable containers. Carefully collect remainder. Then store and dispose of according to local regulations.
Separated from strong oxidants. Well closed.
Exposure Summary
Biological Exposure Indices (BEI) [ACGIH] - Cobalt in urine = 15 ug/L; sample at end of shift at end of workweek;
ACGIH - Documentation of the TLVs and BEIs, 7th Ed. Cincinnati: ACGIH Worldwide, 2020.
0.02 [mg/m3], as Co
The aerosol is irritating to the eyes and respiratory tract.
Repeated or prolonged contact may cause skin sensitization.
Fire Prevention
NO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust.
Exposure Prevention
PREVENT DISPERSION OF DUST! STRICT HYGIENE!
Inhalation Prevention
Use local exhaust or breathing protection.
Skin Prevention
Protective gloves. Protective clothing.
Eye Prevention
Wear safety goggles or eye protection in combination with breathing protection if powder.
Ingestion Prevention
Do not eat, drink, or smoke during work. Wash hands before eating.
UN Hazard Class: 4.1; UN Pack Group: III
Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, causing increased lipid peroxidation, DNA damage, and inducing certain enzymes that lead to cell apoptosis. Cobalt has also been shown to block inorganic calcium channels, possibly impairing neurotransmission. Cobalt can also chelate lipoic acids, impairing oxidation of pyruvate or fatty acids. In addition, cobalt may inhibit DNA repair by interacting with zinc finger DNA repair proteins, and has also been shown to inhibit heme synthesis and glucose metabolism. Cobalt may activate specific helper T-lymphocyte cells and interact directly with immunologic proteins, such as antibodies (IgA and IgE) or Fc receptors, resulting in immunosensitization. (L29)
L29: ATSDR - Agency for Toxic Substances and Disease Registry (2004). Toxicological profile for cobalt. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). http://www.atsdr.cdc.gov/toxprofiles/tp.asp?id=373&tid=64
Carcinogen Classification
2B, possibly carcinogenic to humans. (L135)
L29: ATSDR - Agency for Toxic Substances and Disease Registry (2004). Toxicological profile for cobalt. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). http://www.atsdr.cdc.gov/toxprofiles/tp.asp?id=373&tid=64
L30: Wikipedia. Cobalt. Last Updated 21 March 2009. http://en.wikipedia.org/wiki/Cobalt
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.
Inhalation (L29) ; oral (L29) ; dermal (L29)
L29: ATSDR - Agency for Toxic Substances and Disease Registry (2004). Toxicological profile for cobalt. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). http://www.atsdr.cdc.gov/toxprofiles/tp.asp?id=373&tid=64
Inhalation Exposure
Cough. Shortness of breath. Sore throat. Wheezing.
Skin Exposure
Redness. Pain.
Ingestion Exposure
Diarrhoea. Weakness.
L2090: U.S. National Library of Medicine, MedlinePlus: Cobalt poisoning. http://www.nlm.nih.gov/medlineplus/ency/article/002495.htm
Skin Sensitizer - An agent that can induce an allergic reaction in the skin.
LD50: 3900 mg/kg (Oral, Rat) (L491)
L491: ScienceLab.com (2008). Material Safety Data Sheet (MSDS) for Cobalt naphthenate, 53% in mineral spirits. http://www.sciencelab.com/xMSDS-Cobalt_naphthenate_53_in_mineral_spirits-9927740
Chronic Inhalation: 0.0001 mg/m3 (L134)
Intermediate Oral: 0.01 mg/kg/day (L134)
L134: ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). http://www.atsdr.cdc.gov/mrls/
Treatment of cobalt poisoning is symptomatic. (L29)
L29: ATSDR - Agency for Toxic Substances and Disease Registry (2004). Toxicological profile for cobalt. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). http://www.atsdr.cdc.gov/toxprofiles/tp.asp?id=373&tid=64
Associated Occupational Diseases with Exposure to the Compound
Contact dermatitis, allergic [Category: Skin Disease]
- ChemIDplusCobaltous 2-naphthenic acidhttps://pubchem.ncbi.nlm.nih.gov/substance/?source=chemidplus&sourceid=0157583329ChemIDplus Chemical Information Classificationhttps://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus
- FDA Global Substance Registration System (GSRS)LICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linkingCOBALTOUS 2-NAPHTHENIC ACIDhttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/9M0814DLOU
- ILO-WHO International Chemical Safety Cards (ICSCs)COBALT NAPHTHENATEhttps://www.ilo.org/dyn/icsc/showcard.display?p_version=2&p_card_id=1093
- NJDOH RTK Hazardous Substance Listcobalt naphthenatehttp://nj.gov/health/eoh/rtkweb/documents/fs/0523.pdf
- Consumer Product Information Database (CPID)LICENSECopyright (c) 2024 DeLima Associates. All rights reserved. Unless otherwise indicated, all materials from CPID are copyrighted by DeLima Associates. No part of these materials, either text or image may be used for any purpose other than for personal use. Therefore, reproduction, modification, storage in a retrieval system or retransmission, in any form or by any means, electronic, mechanical or otherwise, for reasons other than personal use, is strictly prohibited without prior written permission.https://www.whatsinproducts.com/contents/view/1/6Cobalt naphthenatehttps://www.whatsinproducts.com/chemicals/view/1/474/061789-51-3Consumer Products Category Classificationhttps://www.whatsinproducts.com/
- Haz-Map, Information on Hazardous Chemicals and Occupational DiseasesLICENSECopyright (c) 2022 Haz-Map(R). All rights reserved. Unless otherwise indicated, all materials from Haz-Map are copyrighted by Haz-Map(R). No part of these materials, either text or image may be used for any purpose other than for personal use. Therefore, reproduction, modification, storage in a retrieval system or retransmission, in any form or by any means, electronic, mechanical or otherwise, for reasons other than personal use, is strictly prohibited without prior written permission.https://haz-map.com/AboutCobalt naphthenatehttps://haz-map.com/Agents/8037
- Toxin and Toxin Target Database (T3DB)LICENSET3DB is offered to the public as a freely available resource. Use and re-distribution of the data, in whole or in part, for commercial purposes requires explicit permission of the authors and explicit acknowledgment of the source material (T3DB) and the original publication.http://www.t3db.ca/downloadsCobalt(II) naphthenatehttp://www.t3db.ca/toxins/T3D0663
- Wikidatacobaltous 2-naphthenic acidhttps://www.wikidata.org/wiki/Q1944114
- PubChem
- Medical Subject Headings (MeSH)LICENSEWorks produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.https://www.nlm.nih.gov/copyright.htmlnaphthenic acidhttps://www.ncbi.nlm.nih.gov/mesh/67046170
- EPA Substance Registry ServicesEPA SRS List Classificationhttps://sor.epa.gov/sor_internet/registry/substreg/LandingPage.do
- MolGenieMolGenie Organic Chemistry Ontologyhttps://github.com/MolGenie/ontology/
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