Inhibition of class II FBA
- Deposit:2010-05-25
- Modify:2022-08-30
Title: New competitive inhibitors of cytosolic (NADH-dependent) rabbit muscle glycerophosphate dehydrogenase.
Abstract: We report the synthesis and biochemical evaluation of new competitive inhibitors of the cytosolic (NADH-dependent) glycerophosphate dehydrogenase. The best tested compound, phosphono-propionohydroxamic acid, with a Ki of 6 microM, might be of interest as an anti-obesity drug.
Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.
Journal: Bioorg Med Chem Lett
Year: 2007
Volume: 17
Issue: 2
First Page: 410
Last Page: 413
DOI: 10.1016/j.bmcl.2006.10.030
- PubChem
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