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Inhibition of class II FBA

PubChem AID
292821
Primary Citation
New competitive inhibitors of cytosolic (NADH-dependent) rabbit muscle glycerophosphate dehydrogenase [PMID: 17088060]
Source
External ID
BioAssay Type
Confirmatory
Tested Substances
Tested Compounds
Version
Status
Live
Dates
  • Deposit:
    2010-05-25
  • Modify:
    2022-08-30
Description
This bioassay record (AID 292821) reports results from the above primary citation. Additional data from the same publication are reported in a total of 3 BioAssay records in PubChem.

1 Description

Title: New competitive inhibitors of cytosolic (NADH-dependent) rabbit muscle glycerophosphate dehydrogenase.

Abstract: We report the synthesis and biochemical evaluation of new competitive inhibitors of the cytosolic (NADH-dependent) glycerophosphate dehydrogenase. The best tested compound, phosphono-propionohydroxamic acid, with a Ki of 6 microM, might be of interest as an anti-obesity drug.

2 Comment

Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett

Year: 2007

Volume: 17

Issue: 2

First Page: 410

Last Page: 413

DOI: 10.1016/j.bmcl.2006.10.030

3 Result Definitions

4 Data Table

6 Identity

6.1 BioAssay Name

Inhibition of class II FBA

6.2 Source

6.3 External ID

6.4 Project Category

Literature, Extracted

6.5 BioAssay Type

Confirmatory

6.6 Deposit Date

2010-05-25

6.7 Modify Date

Version 1.1
Version 2.1
Version 2.2
Version 2.3
Version 3.1
Version 3.2
Version 3.3
Version 4.1
Version 5.1
Version 6.1
Version 6.2
Version 7.1
Version 7.2
2022-08-30 (currently shown)

6.8 Status

Live

7 Same-Publication BioAssays

8 BioAssay Annotations

Assay Type
Binding
Assay Organism

9 Information Sources

  1. PubChem
  2. ChEMBL
    LICENSE
    Access to the web interface of ChEMBL is made under the EBI's Terms of Use (http://www.ebi.ac.uk/Information/termsofuse.html). The ChEMBL data is made available on a Creative Commons Attribution-Share Alike 3.0 Unported License (http://creativecommons.org/licenses/by-sa/3.0/).
    http://www.ebi.ac.uk/Information/termsofuse.html
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