Inhibitory concentration against recombinant human Cathepsin L at 37 degree C at pH 5.5
- Deposit:2010-05-24
- Modify:2022-08-30
Title: Design and synthesis of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 1.
Abstract: A series of Nalpha-acyl-alpha-amino acid-(arylaminoethyl)amides were found to be potent and noncovalent cathepsin S inhibitors. Compound 20 possessed high cathepsin S affinity (Ki=3.3 nM) and showed excellent selectivity over cathepsin K, L, F, and V. Molecular modeling, design, synthesis, and in vitro activity are described.
Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.
Journal: Bioorg Med Chem Lett
Year: 2005
Volume: 15
Issue: 22
First Page: 4979
Last Page: 4984
DOI: 10.1016/j.bmcl.2005.08.017
Target ChEMBL ID: CHEMBL3837
ChEMBL Target Name: Cathepsin L
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
- PubChem
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