Inhibition of human recombinant Vps34 using substrate PI incubated for 1 hr by Adapta kinase assay
- Deposit:2018-09-07
- Modify:2022-08-30
Title: Class II Phosphoinositide 3-Kinases as Novel Drug Targets.
Abstract: The phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases central to regulating a wide range of important intracellular processes. Despite the vast knowledge around class I PI3Ks, the class II PI3Ks have been neglected, seemingly only due to the chronology of their discovery. Here we focus on the cellular functions of the three class II PI3K isoforms, PI3KC2α, PI3KC2β, and PI3KC2γ, in different cell systems and underline the emerging importance of these enzymes in different physiological and pathological contexts. We provide an overview on the current development of class II PI3 kinase inhibitors and outline the potential use for such inhibitors. The field is in its infancy as compared to their class I counterparts. Nevertheless, recent advances in understanding the roles of class II PI3 kinases in different pathological contexts is leading to an increased interest in the development of specific inhibitors that can provide potential novel pharmacological tools.
Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.
Journal: J Med Chem
Year: 2017
Volume: 60
Issue: 1
First Page: 47
Last Page: 65
DOI: 10.1021/acs.jmedchem.6b00963
Target ChEMBL ID: CHEMBL1075165
ChEMBL Target Name: Phosphatidylinositol 3-kinase catalytic subunit type 3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
- PubChem
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