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Antagonist activity at human GPR43 expressed in U2OS cells by BacMam FLIPR/summary (Abse5) assay

PubChem AID
1178833
Primary Citation
Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120) [PMID: 24881566]
Source
External ID
BioAssay Type
Confirmatory
Tested Substances
Tested Compounds
Version
Status
Live
Dates
  • Deposit:
    2016-05-21
  • Modify:
    2018-10-05
Description
This bioassay record (AID 1178833) reports results from the above primary citation. Additional data from the same publication are reported in a total of 194 BioAssay records in PubChem.

1 Description

Title: Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120).

Abstract: The exploration of a diarylsulfonamide series of free fatty acid receptor 4 (FFA4/GPR120) agonists is described. This work led to the identification of selective FFA4 agonist 8 (GSK137647A) and selective FFA4 antagonist 39. The in vitro profile of compounds 8 and 39 is presented herein.

2 Comment

Journal: Bioorg Med Chem Lett

Year: 2014

Volume: 24

Issue: 14

First Page: 3100

Last Page: 3103

DOI: 10.1016/j.bmcl.2014.05.012

Target ChEMBL ID: CHEMBL5493

ChEMBL Target Name: Free fatty acid receptor 2

ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain

Relationship Type: D - Direct protein target assigned

Confidence: Direct single protein target assigned

3 Result Definitions

4 Data Table

5 Target

8 Identity

8.1 BioAssay Name

Antagonist activity at human GPR43 expressed in U2OS cells by BacMam FLIPR/summary (Abse5) assay

8.2 Source

8.3 External ID

8.4 Project Category

Literature, Extracted

8.5 BioAssay Type

Confirmatory

8.6 Deposit Date

2016-05-21

8.7 Modify Date

Version 1.1
Version 1.2
Version 2.1
2018-10-05 (currently shown)

8.8 Status

Live

9 Same-Publication BioAssays

10 BioAssay Annotations

Assay Format
Cell-based
Assay Type
Binding
Assay Cell Type
Assay Organism

11 Information Sources

  1. PubChem
  2. ChEMBL
    LICENSE
    Access to the web interface of ChEMBL is made under the EBI's Terms of Use (http://www.ebi.ac.uk/Information/termsofuse.html). The ChEMBL data is made available on a Creative Commons Attribution-Share Alike 3.0 Unported License (http://creativecommons.org/licenses/by-sa/3.0/).
    http://www.ebi.ac.uk/Information/termsofuse.html
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