Sulfur carrier protein ThiS adenylyltransferase (EC 2.7.7.73)
Enzyme
Enzyme Class
- EC 2.-.-.- Transferases
- EC 2.7.-.- Transferring phosphorus-containing groups
- EC 2.7.7.- Nucleotidyltransferases
Dates
- Modify:2025-01-18
Description
The enzyme catalyzes the adenylation of ThiS, a sulfur carrier protein involved in the biosynthesis of thiamine
The enzyme shows significant structural similarity to ubiquitin- activating enzyme
In Escherichia coli, but not in Bacillus subtilis, the enzyme forms a cross link from Cys-184 to the ThiS carboxy terminus (the position that is also thiolated) via an acyldisulfide
Formerly EC 2.7.7.n3
ATP + [ThiS] = diphosphate + adenylyl-[ThiS]
Zn(2+)
- ENZYMELICENSECopyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/).https://enzyme.expasy.org/enzyme.get
- Rhea - annotated reactions databaseLICENSERhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.https://www.rhea-db.org/help/license-disclaimer
CONTENTS