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Sulfur carrier protein ThiS adenylyltransferase (EC 2.7.7.73)

Enzyme
Enzyme Class
Dates
  • Modify:
    2025-01-18
Description

The enzyme catalyzes the adenylation of ThiS, a sulfur carrier protein involved in the biosynthesis of thiamine

The enzyme shows significant structural similarity to ubiquitin- activating enzyme

In Escherichia coli, but not in Bacillus subtilis, the enzyme forms a cross link from Cys-184 to the ThiS carboxy terminus (the position that is also thiolated) via an acyldisulfide

Formerly EC 2.7.7.n3

1 Biochemical Reactions

2 Catalytic Activity

ATP + [ThiS] = diphosphate + adenylyl-[ThiS]

3 Cofactors

Zn(2+)

4 Information Sources

  1. ENZYME
    LICENSE
    Copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/).
    https://enzyme.expasy.org/enzyme.get
  2. Rhea - annotated reactions database
    LICENSE
    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
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