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Glycogen phosphorylase (EC 2.4.1.1)

Enzyme
Enzyme Class
Dates
  • Modify:
    2025-01-26
Description

This entry covers several enzymes from different sources that act in vivo on different forms of (1->4)-alpha-D-glucans

Some of these enzymes catalyze the first step in the degradation of large branched glycan polymers - the phosphorolytic cleavage of alpha-1,4-glucosidic bonds from the non-reducing ends of linear poly(1->4)-alpha-D-glucosyl chains within the polymers

The enzyme stops when it reaches the fourth residue away from an alpha-1,6 branching point, leaving a highly branched core known as a limit dextrin

The description (accepted name) of the enzyme should be modified for each specific instance by substituting 'glycogen' with the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, etc

1 Names and Identifiers

1.1 Synonyms

  • Amylophosphorylase
  • Muscle phosphorylase a and b
  • Polyphosphorylase

1.1.1 MeSH Entry Terms

Phosphorylase ab

2 Chemicals and Bioactivities

2.1 Tested Compounds

3 BioAssays

4 Protein Targets

5 Pathways

6 Biochemical Reactions

7 Catalytic Activity

((1->4)-alpha-D-glucosyl)(n) + phosphate = ((1->4)-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate

8 Literature

8.1 NLM Curated PubMed Citations

8.2 Protein-Chemical Co-Occurrences in Literature

8.3 Protein-Gene Co-Occurrences in Literature

8.4 Protein-Disease Co-Occurrences in Literature

9 Patents

9.1 Protein-Chemical Co-Occurrences in Patents

9.2 Protein-Gene Co-Occurrences in Patents

10 Information Sources

  1. ENZYME
    LICENSE
    Copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/).
    https://enzyme.expasy.org/enzyme.get
  2. PubChem
  3. Medical Subject Headings (MeSH)
    LICENSE
    Works produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.
    https://www.nlm.nih.gov/copyright.html
  4. Rhea - annotated reactions database
    LICENSE
    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
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