RHOB GTPase cycle
Pathway
Source
Taxonomic Scope
organism_specific
Taxonomy
Category
pathway
Dates
- Create:2021-04-02
- Modify:2024-11-01
Description
This pathway catalogues RHOB guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs), GDP dissociation inhibitors (GDIs) and RHOB effectors. RHOB belongs to the RHOA subfamily of RHO GTPases and shares 85% sequence identity with RHOA and RHOC. Posttranslational modifications of the unique C-terminus of RHOB regulate its subcellular localization. Similar to RHOA and RHOC, RHOB regulates the cytoskeleton and plays a role in cell migration. RHOB plays a role in regulation of membrane trafficking (Vega and Ridley 2018), cell proliferation (Vega and Ridley 2018), cell adhesion (Vega and Ridley 2018), DNA repair (Vega and Ridley 2018), and apoptosis (Prendergast 2001; Vega and Ridley 2018). RHOB-regulated cellular processes are important for the immune system function (Vega and Ridley 2018), pulmonary gas exchange (Wojciak-Stothard et al. 2012; Vega and Ridley 2018), and angiogenesis and vascular function (Vega and Ridley 2018). RHOB has been implicated both as a tumor suppressor and as an oncogene in cancer (Prendergast 2001; Huang and Prendergast 2006; Ju and Gilkes 2018; Calvayrac et al. 2018).
PubChem Protein
GlycoProtein
PubChem Protein
GlycoProtein
- ReactomeLICENSEReactome is an open source and open access resource, available to anyone and covered by two Creative Commons licenses: the terms of the Creative Commons Public Domain (CC0) License apply to all Reactome annotation files, e.g. identifier mapping data, specialized data files, and interaction data derived from Reactome; the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License apply to all software and code, e.g. relating to the functionality of the reactome.org, derived websites and webservices, the Curator Tool, the Functional Interaction application, SQL and Graph Database data dumps, and Pathway Illustrations (Enhanced High-Level Diagrams), Icon Library, Art and Branding Materials.https://reactome.org/license
- PubChem
- GlyCosmos Glycoscience PortalLICENSEAll copyrightable parts of the datasets in GlyCosmos are under the Creative Commons Attribution (CC BY 4.0) License.https://glycosmos.org/license
CONTENTS