TRAF6 mediated IRF7 activation
Pathway
Source
Taxonomic Scope
organism_specific
Taxonomy
Category
pathway
Dates
- Create:2019-01-17
- Modify:2025-01-01
Description
TRAF6 is crucial for both DDX58 (RIG-I)- and IFIH1 (MDA5)-mediated antiviral responses. The absence of TRAF6 resulted in enhanced viral replication and a significant reduction in the production of type I IFNs and IL6 after infection with RNA virus. Activation of NF-kB and IRF7, but not that of IRF3, was significantly impaired during RIG-like helicases (RLHs) signaling in the absence of TRAF6. TRAF6-induced activation of IRF is likely to be specific for IRF7, while TRAF3 is thought to activate both IRF3 and IRF7. These results strongly suggest that the TRAF6- and TRAF3-dependent pathways are likely to bifurcate at mitochondrial antiviral-signaling protein MAVS (IPS-1), but to converge later at IRF7 in order to co-operatively induce sufficient production of type I IFNs during RLH signaling.
PubChem Protein
GlycoProtein
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- PubChem
- GlyCosmos Glycoscience PortalLICENSEAll copyrightable parts of the datasets in GlyCosmos are under the Creative Commons Attribution (CC BY 4.0) License.https://glycosmos.org/license
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