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Novel inhibitors of formation of advanced glycation endproducts (ages)

Patent
WO-02072083-A1
Inventor

RAHBAR SAMUEL

LALEZARI IRAJ

Assignee
HOPE CITY (US)
Country
WIPO (PCT)
Dates
  • Priority:
    2001/03/08
Description
This web page summarizes information in PubChem about patent WO-02072083-A1. This includes chemicals mentioned, as reported by PubChem contributors, as well as other content, such as title, abstract, and International Patent Classification (IPC) codes. To read more about how this page was constructed, please visit the PubChem patents help page.

1 Abstract

The nonenzymatic glycation and crosslinking of proteins is a part of the aging process with the glycation endproducts and crosslinking of long-lived proteins increasing with age. This process is increased at elevated concentrations of reducing sugars in the blood and in the intracellular environment such as occurs with diabetes. The structural and functional integrity of the affected molecules become perturbed by these modifications and can result in severe consequences. The compounds of the present invention can be used to inhibit this process of nonenzymatic glycation and therefore to inhibit some of the ill effects caused by diabetes or by aging. The compounds are also useful for preventing premature aging, spoilage of proteins in food and can prevent discoloration of teeth.

2 Full Text

3 Important Dates

3.1 Priority Date

2001/03/08

3.2 Filing Date

2002/03/06

3.3 Publication Date

2002/09/19

4 Inventor

RAHBAR SAMUEL

LALEZARI IRAJ

5 Assignee

HOPE CITY (US)

6 Country

WIPO (PCT)

7 Linked Chemicals

7.1 PubChem Compounds

7.2 PubChem Substances

8 Patent Family

9 Classification

9.1 IPC

A61K31/192 (inventive)

A61K31/167 (inventive)

A61P31/10 (inventive)

C07D211/60 (inventive)

A61P19/02 (inventive)

A61K31/17 (inventive)

A61P25/28 (inventive)

A61K31/435 (inventive)

A61P13/00 (inventive)

C07C217/84 (inventive)

A61K31/155 (inventive)

A61P43/00 (inventive)

A23L1/30 (inventive, first)

A61P3/10 (inventive)

A61K31/198 (inventive)

C07C275/34 (inventive)

A61P25/00 (inventive)

A23L3/3526 (inventive)

A61K31/445 (inventive)

A61K31/196 (inventive)

C07C235/24 (inventive)

A61P29/00 (inventive)

A61K31/195 (inventive)

A61P9/10 (inventive)

C07C275/40 (inventive)

A61K31/197 (inventive)

9.2 CPC

A61P9/10 (inventive)

A61P43/00 (inventive)

A61P3/10 (inventive)

A61P31/10 (inventive)

A61P29/00 (inventive)

A61P25/00 (inventive)

A61P25/28 (inventive)

A23L3/3526 (inventive)

A61K31/195 (inventive)

A61K31/192 (inventive, first)

A61P13/00 (inventive)

A61K31/435 (inventive)

A61K31/198 (inventive)

A61K31/17 (inventive)

A61K31/606 (inventive)

A61K31/167 (inventive)

A61P19/02 (inventive)

A61K31/155 (inventive)

10 Citations

  • WO-0059875-A2 (A) (ISR)
  • RAHBAR S ET AL: "NOVEL INHIBITORS OF ADVANCED GLYCATION ENDPRODUCTS", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 262, 1999, pages 651 - 656, XP000946146, ISSN: 0006-291X (DA) (ISR)

11 Cited By

12 Similar Patents

13 Information Sources

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