siah2.L - siah E3 ubiquitin protein ligase 2 L homeolog (African clawed frog)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2025-01-07
- Xsiah-2
- siah2
- siah2-A
- xsiah2
- E3 ubiquitin-protein ligase siah2
- RING-type E3 ubiquitin transferase SIAH2
- seven in absentia homolog 2
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in eye morphogenesis, probably triggers the ubiquitin-mediated degradation of different substrates (PMID: 11335112). May play a role in the regulation of the cellular clock function (By similarity).
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- PubChem
- NCBI Gene Expression Omnibus (GEO)
- Swiss Institute of Bioinformatics Bgee
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- XenbaseLICENSECreative Commons Attribution 3.0 International License (CC BY 3.0)https://www.xenbase.org/xenbase/static-xenbase/aboutMOD.jsp
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