rnf8.S - ring finger protein 8, E3 ubiquitin protein ligase S homeolog (African clawed frog)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2025-01-18
- rnf8
- rnf8-a
- rnf8-b
- E3 ubiquitin-protein ligase rnf8-A
- E3 ubiquitin-protein ligase RNF8-A
- RING finger protein 8 A
- RING-type E3 ubiquitin transferase rnf8-A
- ring finger protein (C3HC4 type) 8
E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated mdc1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of tp53bp1 and brca1 ionizing radiation-induced foci (IRIF). H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains, leading to degradation of substrate proteins. In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation.
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- PubChem
- Swiss Institute of Bioinformatics Bgee
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