SUN1 - SAD1/UNC-84 domain protein 1 (thale cress)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2025-01-20
Description
Encodes a member of the Sad1/UNC-84 (SUN)-domain proteins: AtSUN1(At5g04990), AtSUN2(AT3G10730). SUN domain proteins are part of the cytoskeletal-nucleoskeletal bridging complexes. AtSUN1 and AtSUN2 are localized to the nuclear envelope and are present as homomers and heteromers in vivo.Encodes an outer nuclear membrane protein that anchors RanGAP1 to the nuclear envelope. It interacts with WPP domain interacting-proteins (WIPs). It is involved in maintaining the elongated nuclear shape of epidermal cells.
- ARABIDOPSIS SAD1/UNC-84 DOMAIN PROTEIN 1
- ATSUN1
- MUG13.15
- MUG13_15
- SAD1/UNC-84 domain protein 1
Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments (PMID: 24667841, PMID: 25759303). Required for the maintenance and/or formation of polarized nuclear shape in root hairs (PMID: 21294795, PMID: 25759303). Modulates the anchoring and mobility of WIP proteins and RANGAP1 in the nuclear envelope (NE) (PMID: 22270916). In association with SUN2, may be involved in telomere attachment to nuclear envelope in the prophase of meiosis (PMID: 25412930). As component of the SUN-WIP-WIT2-KAKU1 complex, mediates the transfer of cytoplasmic forces to the nuclear envelope (NE), leading to nuclear shape changes (PMID: 25759303).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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- PubChem
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- STRING: functional protein association networks
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