An official website of the United States government

SUN1 - SAD1/UNC-84 domain protein 1 (thale cress)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-20
Description
Encodes a member of the Sad1/UNC-84 (SUN)-domain proteins: AtSUN1(At5g04990), AtSUN2(AT3G10730). SUN domain proteins are part of the cytoskeletal-nucleoskeletal bridging complexes. AtSUN1 and AtSUN2 are localized to the nuclear envelope and are present as homomers and heteromers in vivo.Encodes an outer nuclear membrane protein that anchors RanGAP1 to the nuclear envelope. It interacts with WPP domain interacting-proteins (WIPs). It is involved in maintaining the elongated nuclear shape of epidermal cells.

1 Names and Identifiers

1.1 Synonyms

  • ARABIDOPSIS SAD1/UNC-84 DOMAIN PROTEIN 1
  • ATSUN1
  • MUG13.15
  • MUG13_15
  • SAD1/UNC-84 domain protein 1

2 Proteins

2.1 Protein Function

Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments (PMID: 24667841, PMID: 25759303). Required for the maintenance and/or formation of polarized nuclear shape in root hairs (PMID: 21294795, PMID: 25759303). Modulates the anchoring and mobility of WIP proteins and RANGAP1 in the nuclear envelope (NE) (PMID: 22270916). In association with SUN2, may be involved in telomere attachment to nuclear envelope in the prophase of meiosis (PMID: 25412930). As component of the SUN-WIP-WIT2-KAKU1 complex, mediates the transfer of cytoplasmic forces to the nuclear envelope (NE), leading to nuclear shape changes (PMID: 25759303).

2.2 Protein 3D Structures

2.2.1 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

2.3 Protein Targets

3 Interactions and Pathways

3.1 Interactions

4 Literature

4.1 Consolidated References

4.2 Gene-Chemical Co-Occurrences in Literature

4.3 Gene-Gene Co-Occurrences in Literature

4.4 Gene-Disease Co-Occurrences in Literature

5 Patents

5.1 Gene-Chemical Co-Occurrences in Patents

5.2 Gene-Gene Co-Occurrences in Patents

5.3 Gene-Disease Co-Occurrences in Patents

6 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. BioGRID
    LICENSE
    The MIT License (MIT); Copyright Mike Tyers Lab
    https://wiki.thebiogrid.org/doku.php/terms_and_conditions
  4. STRING: functional protein association networks
  5. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  6. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
CONTENTS