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MCAN_RS13080 - 2-oxoacid:acceptor oxidoreductase subunit alpha (Mycobacterium canettii CIPT 140010059)

Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-21

1 Names and Identifiers

1.1 Synonyms

MCAN_24941

1.2 Other Identifiers

1.2.1 Enzyme Commission (EC) Number

2 Proteins

2.1 Protein Function

Component of KG oxidoreductase (KOR) that catalyzes the CoA-dependent oxidative decarboxylation of 2-oxoglutarate (alpha-ketoglutarate, KG) to succinyl-CoA. Methyl viologen can act as electron acceptor in vitro; the physiologic electron acceptor is unknown. Is involved in the alternative TCA pathway that functions concurrently with fatty acid beta-oxidation. Since a growing body of evidence indicates that lipids (for example cholesterol and fatty acids) are a predominant growth substrate for M.tuberculosis during infection, flux through KOR likely represents an important step in intermediary metabolism in vivo. KOR-dependent decarboxylation of KG also appears to be an important source of CO(2) in M.tuberculosis metabolism.

2.2 Protein Targets

3 Interactions and Pathways

3.1 Interactions

3.2 Pathways

4 Biochemical Reactions

5 Literature

5.1 Gene-Chemical Co-Occurrences in Literature

5.2 Gene-Gene Co-Occurrences in Literature

5.3 Gene-Disease Co-Occurrences in Literature

6 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. STRING: functional protein association networks
  4. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  5. Rhea - annotated reactions database
    LICENSE
    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
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