CD86 - CD86 molecule (human)
- Create:2016-09-14
- Modify:2025-02-02
- B7-2
- B7.2
- B70
- CD28LG2
- LAB72
- T-lymphocyte activation antigen CD86
- B-lymphocyte activation antigen B7-2
- BU63
- CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
- CTLA-4 counter-receptor B7.2
- FUN-1
Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4 (PMID: 12196291). May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation (PMID: 7527824). Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity).
Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
(Microbial infection) Acts as a receptor for adenovirus subgroup B.
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