TNFRSF10A - TNF receptor superfamily member 10a (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2024-12-18
Description
The protein encoded by the TNFRSF10A gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]
Enables identical protein binding activity and protease binding activity. Involved in TRAIL-activated apoptotic signaling pathway and cellular response to mechanical stimulus. Located in several cellular components, including Golgi apparatus; cell surface; and membrane raft. Is active in plasma membrane raft. Implicated in carcinoma (multiple); cervical cancer; hematologic cancer (multiple); and urinary bladder cancer. Biomarker of breast ductal carcinoma and renal cell carcinoma.
- APO2
- CD261
- DR4
- TRAILR-1
- TRAILR1
- tumor necrosis factor receptor superfamily member 10A
- TNF-related apoptosis-inducing ligand receptor 1
- TRAIL receptor 1
- TRAIL-R1
- cytotoxic TRAIL receptor
- death receptor 4
- tumor necrosis factor receptor superfamily, member 10a
- APO2 Receptor
- CD262 Antigen
- CD261 Antigen
- CD264 Antigen
- DCR2 Receptor
- DR5 Receptor
- DR4 Receptor
- Death Receptor-4
- Death Receptor-5
- Decoy Receptor 2, Tumor Necrosis Factor
- Receptor, TRAIL-4
- Receptor, TRAIL-1
- Receptor, TRAIL-2
- Receptors, TRAIL
- Receptors, Tumor Necrosis Factor, Member 10b
- Receptors, Tumor Necrosis Factor, Member 10
- Receptors, Tumor Necrosis Factor, Member 10d
- Receptors, Tumor Necrosis Factor, Member 10a
- TNF-Related Apoptosis-Inducing Ligand Receptors
- TNF-Related Apoptosis-Inducing Ligand Receptor 2
- TRAIL Receptor 2
- TRAIL Receptor 1
- TRAIL Receptor 4
- TRAIL Receptors
- Tumor Necrosis Factor Receptor Superfamily, Member 10
- Tumor Necrosis Factor Receptor Superfamily, Member 10a
- Tumor Necrosis Factor Receptor Superfamily, Member 10b
Receptor for the cytotoxic ligand TNFSF10/TRAIL (PMID: 26457518, PMID: 38532423). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (PMID: 19090789). Promotes the activation of NF-kappa-B (PMID: 9430227).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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