InR - Insulin-like receptor (fruit fly)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2025-01-17
Description
Enables insulin binding activity and insulin receptor activity. Involved in several processes, including germ cell development; negative regulation of behavior; and positive regulation of cell development. Located in plasma membrane. Part of insulin receptor complex. Is expressed in several structures, including adult fat body; corpus allatum; ganglia; gut section; and somatic precursor cell. Used to study alcohol dependence; diabetic neuropathy; glucose metabolism disease (multiple); high grade glioma; and sleep disorder. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); glucose metabolism disease (multiple); kidney cancer (multiple); liver disease (multiple); and reproductive organ cancer (multiple). Orthologous to several human genes including IGF1R (insulin like growth factor 1 receptor) and INSRR (insulin receptor related receptor).
- 18402
- CG18402
- DIHR
- DILR
- DIR
- DIRH
- DIRbeta
- DInR
- DInr
- Dir-a
- Dir-b
- Dmel\CG18402
- INR
- INS
- IR
- Igfr1
- Inr
- Inr-alpha
- Inr-beta
- InsR
- RTK
- dINR
- dINSR
- dIR
- dIRH
- dInR
- dInr
- dInsR
- dinR
- dinr
- dir
- er10
- inR
- inr
- insulin/insulin-like growth factor receptor
- l(3)05545
- l(3)93Dj
- l(3)er10
- lnR
- sprout
- CG18402-PA
- CG18402-PB
- CG18402-PC
- CG18402-PD
- Igf-1 receptor
- InR-PA
- InR-PB
- InR-PC
- InR-PD
- Insulin-receptor
- drosophila insulin receptor
- insulin
- insulin receptor
- insulin receptor homolog
- insulin receptor homologue
- insulin-like receptor
- insulin-like receptor tyrosine kinase
- insulin/IGF receptor
- lethal(3)93Dj
- sprout
- Insulin Receptor beta Chain
- Insulin Receptor alpha Chain
- Insulin Receptor beta Subunit
- Insulin Receptor
- Insulin Receptor Protein-Tyrosine Kinase
- Insulin Receptor alpha Subunit
- Insulin-Dependent Tyrosine Protein Kinase
- Receptors, Insulin
Has a ligand-stimulated tyrosine-protein kinase activity (PMID: 7628438, PMID: 8603594). Regulates cell number and cell size during development by regulating cell growth and survival, affecting body size and organ size, including ovaries and imaginal disks (PMID: 10455177, PMID: 11250149, PMID: 8603594). Plays a role in life-span determination (PMID: 11292875). May be involved in regulation of other neuroendocrine signaling pathways (PMID: 11292875). Involved in the development of the embryonic nervous system (PMID: 7628438). Functions upstream of dock/dreadlocks for photoreceptor (R cell) axon guidance and targeting in the visual system (PMID: 12702880).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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- PubChem
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- STRING: functional protein association networks
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- Swiss Institute of Bioinformatics Bgee
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