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InR - Insulin-like receptor (fruit fly)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-17
Description
Enables insulin binding activity and insulin receptor activity. Involved in several processes, including germ cell development; negative regulation of behavior; and positive regulation of cell development. Located in plasma membrane. Part of insulin receptor complex. Is expressed in several structures, including adult fat body; corpus allatum; ganglia; gut section; and somatic precursor cell. Used to study alcohol dependence; diabetic neuropathy; glucose metabolism disease (multiple); high grade glioma; and sleep disorder. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); glucose metabolism disease (multiple); kidney cancer (multiple); liver disease (multiple); and reproductive organ cancer (multiple). Orthologous to several human genes including IGF1R (insulin like growth factor 1 receptor) and INSRR (insulin receptor related receptor).

1 Names and Identifiers

1.1 Synonyms

  • 18402
  • CG18402
  • DIHR
  • DILR
  • DIR
  • DIRH
  • DIRbeta
  • DInR
  • DInr
  • Dir-a
  • Dir-b
  • Dmel\CG18402
  • INR
  • INS
  • IR
  • Igfr1
  • Inr
  • Inr-alpha
  • Inr-beta
  • InsR
  • RTK
  • dINR
  • dINSR
  • dIR
  • dIRH
  • dInR
  • dInr
  • dInsR
  • dinR
  • dinr
  • dir
  • er10
  • inR
  • inr
  • insulin/insulin-like growth factor receptor
  • l(3)05545
  • l(3)93Dj
  • l(3)er10
  • lnR
  • sprout
  • CG18402-PA
  • CG18402-PB
  • CG18402-PC
  • CG18402-PD
  • Igf-1 receptor
  • InR-PA
  • InR-PB
  • InR-PC
  • InR-PD
  • Insulin-receptor
  • drosophila insulin receptor
  • insulin
  • insulin receptor
  • insulin receptor homolog
  • insulin receptor homologue
  • insulin-like receptor
  • insulin-like receptor tyrosine kinase
  • insulin/IGF receptor
  • lethal(3)93Dj
  • sprout

1.1.1 MeSH Entry Terms

  • Insulin Receptor beta Chain
  • Insulin Receptor alpha Chain
  • Insulin Receptor beta Subunit
  • Insulin Receptor
  • Insulin Receptor Protein-Tyrosine Kinase
  • Insulin Receptor alpha Subunit
  • Insulin-Dependent Tyrosine Protein Kinase
  • Receptors, Insulin

1.2 Other Identifiers

1.2.1 Ensembl ID

1.2.2 Alliance Gene ID

1.2.3 Bgee Gene ID

1.2.4 Enzyme Commission (EC) Number

1.2.5 FlyBase ID

1.2.6 VEuPathDB ID

1.2.7 Wikidata

2 Proteins

2.1 Protein Function

Has a ligand-stimulated tyrosine-protein kinase activity (PMID: 7628438, PMID: 8603594). Regulates cell number and cell size during development by regulating cell growth and survival, affecting body size and organ size, including ovaries and imaginal disks (PMID: 10455177, PMID: 11250149, PMID: 8603594). Plays a role in life-span determination (PMID: 11292875). May be involved in regulation of other neuroendocrine signaling pathways (PMID: 11292875). Involved in the development of the embryonic nervous system (PMID: 7628438). Functions upstream of dock/dreadlocks for photoreceptor (R cell) axon guidance and targeting in the visual system (PMID: 12702880).

2.2 Protein 3D Structures

2.2.1 PDB Structures

2.2.2 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

2.3 Protein Targets

3 BioAssays

3.1 RNAi BioAssays

4 Interactions and Pathways

4.1 Chemical-Gene Interactions

4.2 Interactions

4.3 Pathways

5 Biochemical Reactions

6 Expression

7 Literature

7.1 Consolidated References

7.2 NLM Curated PubMed Citations

7.3 Gene-Chemical Co-Occurrences in Literature

7.4 Gene-Gene Co-Occurrences in Literature

7.5 Gene-Disease Co-Occurrences in Literature

8 Patents

9 Classification

9.1 MeSH Tree

9.2 Gene Ontology: Biological Process

9.3 Gene Ontology: Cellular Component

9.4 Gene Ontology: Molecular Function

10 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Medical Subject Headings (MeSH)
    LICENSE
    Works produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.
    https://www.nlm.nih.gov/copyright.html
  4. Alliance of Genome Resources
    LICENSE
    All annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
    https://www.alliancegenome.org/privacy-warranty-licensing
  5. BioGRID
    LICENSE
    The MIT License (MIT); Copyright Mike Tyers Lab
    https://wiki.thebiogrid.org/doku.php/terms_and_conditions
  6. STRING: functional protein association networks
  7. Comparative Toxicogenomics Database (CTD)
    LICENSE
    It is to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of NC State University.
    http://ctdbase.org/about/legal.jsp
  8. FlyBase
    LICENSE
    All annotations and data produced by FlyBase that are accessible from flybase.org are distributed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
    https://wiki.flybase.org/wiki/FlyBase:About#FlyBase_Licenses_and_Availability
  9. NCBI Gene Expression Omnibus (GEO)
  10. RCSB Protein Data Bank (RCSB PDB)
    LICENSE
    Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data.
    https://www.rcsb.org/pages/policies
  11. Swiss Institute of Bioinformatics Bgee
    LICENSE
    Creative Commons Zero license (CC0)
    https://www.bgee.org/about/
  12. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  13. VEuPathDB: The Eukaryotic Pathogen, Vector and Host Informatics Resource
    LICENSE
    All data on VEuPathDB websites are provided freely for public use.
    https://veupathdb.org/veupathdb/app/static-content/about.html
  14. Wikidata
  15. Gene Ontology (GO)
    LICENSE
    Gene Ontology Consortium data and data products are licensed under the Creative Commons Attribution 4.0 Unported License (https://creativecommons.org/licenses/by/4.0/legalcode)
    http://geneontology.org/docs/go-citation-policy/
  16. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
  17. Rhea - annotated reactions database
    LICENSE
    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
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